A Study Of The Association Between Apolipoprotein B/A1Ratio And Intracranial Atherosclerotic Stenosis

Purpose: To study the relationship between apolipoprotein B/A1ratio andintracranial atherosclerotic stenosis.Methods: We recruited consecutive patients from Department ofNeurology of Jilin University with acute ischemic stroke (≤7days of onset)form January2010through December2011. According neuroimaging andvascular imaging and other clinical data, the patients were categorized into3groups: intracranial (ICAS, n=28), extracranial (n=23), and no cerebralatherosclerotic stenosis (n=30). We recorded the Sex, Age, Onset time toAdmission，Smoking, Hypertension, Diabetes mellitus, CAD, waistline，thelevel of blood pressure to Admission and collected data on intravenous tensionof empty stomach, triglyceride levels, HDL-C levels, LDL-C levels, apoA1levels and apoB levels. Compare the relationship of ApoB/ApoA1, generaldata and MetS between three groups.Results: The ICAS group showed a higher apoB/apoA1ratio (1.09±0.32)than both the extracranial atherosclerotic stenosis (0.90±0.33) and no cerebralatherosclerotic stenosis (0.70±0.30) groups (P＜0.05). We were stratified intoquartiles according to the distribution of their serum apoB/apoAI ratios to showthe relationships of apoB/apoAI ratios,MetS and three groups. Patients withhigher quartiles of the apoB/apoAI ratio had a higher incidence of ICAS (P＜0.05); MetS was more frequent in patients with higher apoB/apoAI ratioquartiles,and Patients with higher quartiles of the apoB/apoAI ratio were morelikely to have a greater number of MetS components. Patients with more MetScomponents had a higher apoB/apoAI ratio:0.72±0.28for0to2MetScomponents;0.96±0.38for3MetS components; and1.07±0.32for≥4MetS components (P＜0.05). Patients with a greater number of MetS componentswere more likely to have ICAS(P＜0.05). The univariate analyses showed thatpatients with higher apoB/apoAI ratio quartiles were associated with anincreased risk for ICAS. Other significant variables associated with increasingICAS risk were hypertension, diabetes, coronary artery disease and MetS.Multivariable analyses showed that the highest apoB/apoAI ratio quartile wassignificantly associated with ICAS, was independent predictors of ICAS (OR，12.47；95%CI，1.89-82.43). Other independent variables for ICAS werehypertension (6.7；1.87-24.00), diabetes (7.82；2.11-28.90), coronary arterydisease (10.49；2.60-42.35), and MetS(2.96；0.88-9.96),Conclusions: A higher apoB/apoAI ratio is a predictor of ICAS ratherthan of extracranial atherosclerotic stenosis or no cerebral atheroscleroticstenosis. The risk of ICAS increased12times with a higher apoB/apoAIratio.The prediction function of higher apoB/apoAI ratio is stronger, comparedwith Hypertension, CAD, Diabetes mellitus and metabolic syndrome. HighapoB/apoAI ratio might be a biomarker of ICAS in China patients with stroke.