The Relationship Between The ApoB/apoA1 Ratio And Cervical Plaque Stability In Patients With Acute Cerebral Infarction

Objective: The purpose of this study is to investigate the relationship between theapo B/apo A1 ratio andcervical plaque stability in patients with acute cerebral infarction,which aims to provide clinical doctors with simple and effectiveclinical indicators to assess cervical plaque stability in patients with acute cerebral infarction.Methods: 94 cases with atherosclerotic acute cerebral infarction in the Neurologic Department in Shengjing Hospital of China Medical University from 2015 to 2017,were collected,including 57 males and 37 females.Age:25-90,the duration of disease is less than 7 days.According to the results of ultrasonic examination of neck blood vessels operated by professional doctors,the cases weredivided into two groups,unstable plaque group(47 cases)and stable plaque group(47 cases).We collected and entered data of risk factors in two groups,included age,sex,hypertension,smoking,hyperlipidemia,the serum level of subclasses ofblood lipids,totalcholesterol(TC),apoprotein B(apo B),apolipoprotein A1(apo A1),triacylglycer ide(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),used the t-test to compared the difference between the two groups.And the ROC curve is used to calculate the optimal boundary value point.Results:(1)Patients in unstable plaque group had high smoking rate(55.3%),which significantly higher than that of patients in stable plaque group(34.0%,P = 0.038).Other risk factors,such as age,gender,hyperlipidemia,and hypertension,were not significantly different.(2)In the unstable plaque group,apo B,LDL,and apo B/apo A1 were significantly higher than those in the stable plaque group,while,there was no significant difference between HDL and apo A1.(3)apo B/apo A1 ratio in patients with acute cerebral infarction has certain predictive power for the unstable plaques of internal carotid artery.(4)apo B/apo A1 ratio and smoking were independent risk factors for internal carotid atherosclerotic plaque in patients with acute cerebral infarction(P<0.05).(5)The optimal value of apo B/apo A1 ratio in diagnosing the stability of internal carotid artery plaque was 0.94.(95% confidence interval: 0.514-0.742,P = 0.033)Conclusion: this study suggests that apo B/apo A1 ratio may be a clinical indicator to predict the stability of atherosclerotic cervical plaque.