The Study Of The Succession Of Phlegm With Stagnant Blood In Metabolic Syndrome And The Correlation With Inflammatory Factors

ObjectiveTo investigate the change of phlegm with stagnant blood and inflammatory factors in mice with metabolic syndrome.To investigate the effect of method of resolving phlegm and removing blood stasis.To discuss the characteristic of Framingham risk factor score in patients with stagnant blood and phlegm.MethodsIn experimental research,72male Sprague Dawley rats were randomly divided into three groups:control group, model group and Chinese medicine-treated group. The control group were feed basic diet, and the rest group were feed high-fat-salt diet in16weeks. The Chinese medicine-treated group were feed Chinese medicine also. And we discuss the change of blood lipid, hemorrheology, blood glucose, inflammatory factors, the modality of aorta at various time pointsIn clinical research,103cases were divided into four groups, namely, retention of qi and phlegm syndrome (RQPS), qi and yin deficiency syndrome (QYDS), phlegm-stasis syndrome(PSS), qi deficiency of spleen and kidney syndrome(QSKY). Weigh、blood pressure、glucose、waist circumference、hip circumference、blood lipid、blood clotting were obtained, and we disuss the Framingham risk factor score in each pattern.ResultsComparison of body weight:the model group in4、8、16week were significant higher(P<0.05).Comparison of abdominal circumference:the model group in4、8、16week were significant higher (P<0.05). The Chinese medicine-treated group in4、8、16week were significant higher(P<0.05).Comparison of blood pressure:the model group in16week were significant higher(P<0.05).Comparison of blood pressure:the model group in8、16week were significant higher(P<0.05).Comparison of blood lipid:TC、LDL-C in the model group in8week were significant higher(P<0.05). TC、TG、LDL-C in the model group in16week were significant higher (P<0.05). LDL-C in the Chinese medicine-treated group in16week were significant higher(P<0.05).Comparison of hemorrheology:blood viscosity low and middle shear、 hematocrit、plasma viscosity in the model group in8week were significant higher (P<0.05). Whole blood viscosity、hematocrit、plasma viscosity in the model group in16week were significant higher(P<0.05). Plasma viscosity in the Chinese medicine-treated group in8、16week were significant higher (P<0.05).Comparison of inflammatory factors:TNF-α、IL-6、CRP in the model group in8、16week were significant higher (P<0.05). TC、TG、LDL-C in the model group in16week were significant higher(P<0.05). IL-6in the Chinese medicine-treated group in8week were significant higher(P<0.05). TNF-α、 CRP in the Chinese medicine-treated group in16week were significant higher(P<0.05).Comparison of aorta score:the model group in4、8、16week were significant higher(P<0.05).Comparison of abdominal circumference、blood pressure:abdominal circumference in PSS group were significant higher than the group of RQPS、 QYDS(P<0.05).Systolic syndrome in PSS group were significant higher than the group of RQPS(P<0.05). Diastolic pressure in the model group were significant higher than the group of RQPS、QYDS、QSKY (P<0.05).Comparison of biochemical indicator:FPG in PSS group were significant higher than the group of RQPS、QYDS(P<0.05). TC in PSS group were significant higher than the group of RQPS、QYDS(P<0.05). TG in the model group were significant higher than the group of RQPS、QYDS、QSKY (P<0.05). Comparison of Framingham risk factor score:PSS group were significant higher than the group of RQPS、QYDS、QSKY (P<0.05).ConclusionThe obstruction of blood vessel become more and more serious, which is accompanied by the blood lipid increased, and it prompts that the blood stasis is due to the phlegm. Traditional Chinese medicine of resolving phlegm and promoting blood can effectively improve the pathology of the phlegm and blood stasis in MS.