The Blood Zinc Concentration In Children With Diarrhea Of320Cases And The Correlation With Clinical Factors

Objective: Zinc deficiency is associated with an increased incidence of diarrhea diseasesin children, the aim of this study was to investigate the blood zinc concentration inchildren with diarrhea, and investigate the association between blood level of zinc withduration, severity of diarrhea, rotavirus detection Etc. Methods: A retrospective analysiswhich include320cases of diarrhea children from pediatric ward of our hospital and400cases of healthy children from child health care department. We evaluated the blood zinclevels during diarrhea children, compared with the healthy children and investigate theassociation between zinc deficiency and duration, temperature and rotavirus detection etc.Measurement data use T-test and count data use2test, test standard＝0.05, betweenthe two groups are compared. Results: Mean blood zinc concentration are significantlylower in the diarrhea children than in the heathy children, respectively (P<0.05). Thefrequency of blood zinc deficiency are significantly higher for the diarrhea children thanthe heathy children, respectively (P<0.05). The highest frequency of zinc deficiency isfound in the early age between0~1years, with the rate of37.1％, there are statisticallysignificant association between the early age group and the another four groups. There areno statistically significant association in gender, birth weight, gestational weeks, feedingpatterns and place of residence of the diarrhea children. Diarrhea children accompany withdifferent duration, severity of diarrhea, the symptoms of fever have higher zinc deficiencyprevalence than the children without these symptoms (P<0.05), diarrhea childrenaccompany with the symptoms of anemia have higher zinc deficiency prevalence than thechildren without the symptoms (P<0.05), the rate of abnormality of the CRP, blooddetection, rotavirus infection for zinc deficiency diarrhea children are higher than withoutzinc deficiency (P<0.05). Conclusion: Blood zinc concentration are significantly lowerand the frequency of zinc deficiency are significantly higher in the diarrhea children thanin the heathy children. There are statistically significant association between zincdeficiency and duration, temperature, severity of diarrhea and rotavirus detection etc.