Thetherapeutic Effectof Bifico And Zinc Preparations In Children With Pneumonia Accompanied With Diarrhea

Objective:To observe the clinical effect of bifico and zinc preparations in the co-treatment of children with pneumonia accompanied with diarrhea.Methods:50 inpatient infants aged 2 to 36 months with pneumonia accompanied with diarrhea were enrolled in patient group, The infants then individually randomized to two groups, the first group were given bifico only, and the other group were given bifico combined with zinc together with anti-infection, symptomatic relief and supportive treatment. In the same period,20 inpatient infants of the same age with pneumonia (the asymptomatic diarrhea happened after 72 h the course of pneumonia, or after 48 h of treatment with antibiotics does not appear as diarrhea) were enrolled in simple pneumonia group. While 50 cases of selected infants in outpatient department of our hospital through physical examination who have not take zinc preparations recently were taken as a control group of healthy children. To observe total effective rate of the two treatment group with detected serum zinc levels of each group and the serum diamine oxidase (DAO) activity, D-lactic acid of patient group, and quantify intestinal bacteria.Results:(1)The serum zinc level in case group was significantly lower than that of the healthy control group (P<0.01). (2) before treatment, the plasma DAO activity, D-lactic acid level and total intestinal bacteria number of the two treatment groups were compared with no significant statistical difference (P >0.05).(3)After treatment the combined treatment group compared with bifico group had higher serum zinc level and the overall effective rate were also higher(P<0.05), serum DAO activity, D-lactic acid was lower(P<0.05).There were significant differences in two groups about the logarithms of two bacterial amounts (copies/g) and B/E value before and after administering(all P<0.05), and no significant difference between them.Conclusions:Infants with pneumonia accompanied with diarrhea compared with the healthy control group had significantly lower serum zinc level. There are intestinal flora imbalance and impaired intestinal mucosal barrier in infants with pneumonia accompanied with diarrhea. Children with pneumonia accompanied with diarrhea appear to benefited from zinc gluconate and bifico supplementation for mucosa functional recovery of the damaged intestinal and to improve the cure rate of diarrhea, it is safe and worthy of clinical application.