Clinical Research On The Rapeutic Effect Of Electroacpuncture At Quchi(LI11) On Blood Plasma NPY And NT Of Essential Hypertension Patients

ObjectiveBy observing the therapeutic effect of electroacupuncture (EA) at Quchi(LI11) on blood pressure and blood plasma NPY and NT of the patient of essential hypertension(EH), And comparing with the control group, And to observe its Short-term efficacy and long-term efficacy. Provide a simple and effective, practical solutions and theoretical support for the prevention and treatment of hypertension.METHODS128cases that met inclusion criteria were randomly divided into an EA group(n=40) and a drug control group (n=40)and an EA with drug control group(the coalescence group)(n=48).In the EA group, bilateral Quchi were selected;in the drug control group,Nicardipine was taken;in the coalescence group,Electroacupuncture combined with drug was given. Observe the changes of the three groups of clinical efficacy and treatment before and after changes in blood pressure and plasma NPY and NT concentration.RESULTS1.In this study, the coalescence group of antihypertensive efficacy superior to the other two groups (P<0.05) after treatment, the EA group and the drug group compared the antihypertensive efficacy was no significant difference (P>0.05). 2.The Changes of systolic blood pressure about three groups of patients before and after treatment.In the EA group and coalescence group, the SBP changes after two weeks of treatment and after four weeks of treatment compared with after one week of treatment was a significant difference (P<0.01). After two weeks of treatment, compared the four weeks after treatment was no significant difference (P>0.05).In the drug group compared to treatment after several treatment are statistically significant (P<0.05).Between the beginning of treatment the combination of group and drug group, significant differences(P <0.05).In treatment of two weeks and four weeks of treatment,the combined group systolic blood pressure decreased extent better than the EA group, drug group (P<0.05);The EA group and drug group did not differ significantly (P>0.05).3.The Changes of diastolic blood pressure about three groups of patients before and after treatment.In the EA group and coalescence group, the DBP changes after two weeks of treatment and after four weeks of treatment compared with after one week of treatment was a significant difference (P<0.01). After two weeks of treatment, compared the four weeks after treatment was no significant difference (P>0.05). After a week of treatment, roughly close among the three groups (P>0.05). In treatment of two weeks and four weeks of treatment,the combined group diastolic blood pressure decreased extent better than the EA group, drug group (P<0.05);The EA group and drug group did not differ significantly (P>0.05).4.The Changes of NPY concentration about three groups of patients before and after treatment.In the three groups, the NPY concentration changes after two weeks of treatment and after four weeks of treatment compared with after one week of treatment was a significant difference (P<0.01). After two weeks of treatment, compared the four weeks after treatment was no significant difference (P>0.05).Between the three groups are statistically significant After a week of treatment, and after two weeks of treatment,and treatment after four weeks (P <0.05).5.The Changes of NT concentration about three groups of patients before and after treatment.In the three groups, the NT concentration changes after two weeks of treatment and after four weeks of treatment compared with after one week of treatment was a significant difference (P<0.01). After two weeks of treatment, compared the four weeks after treatment was no significant difference (P>0.05).Between the three groups are statistically significant After a week of treatment, and treatment after four weeks (P<0.05).After two weeks of treatment, the Rising degree of NT in the combined group than the EA group, drug group (P<0.05);The EA group and drug group did not differ significantly (P>0.05).6.The Changes of NPY/NT concentration about three groups of patients before and after treatment.Three groups within the respective group contrast with NPYandNT changes in volatility remained the same situation.Between the three groups of NPY/NT Ratios are statistically significant After a week of treatment, and after two weeks of treatment,and treatment after four weeks (P<0.05).CONCLUSION1.Study found that three groups of efficacy in the prevention and treatment of hypertension, the combination group than the EA group, drug group,EA group and drug group considerable antihypertensive effect.2. Study found that the effect of long-term efficacy of the EAtreatment of hypertension is stable, effective and reliable,Provide a clinical basis for long-term prevention of hypertension.3.The study found that the EA can effectively regulate neuropeptide Y, neurotensin concentration, and affect the ratio of the neuropeptide Y/neurotensin.Provide an important theoretical basis for the mechanism in the long-term prevention of hypertension.