Hepatitis B Virus Associated Glomerulonephritis Type IgA Syndrome Of Traditional Chinese Medicine

Objective:Through to the renal biopsy confirmed the presence of hepatitis B virus associated glomerulonephritis type IgA syndrome of traditional Chinese medicine research, discuss its pathological typing of TCM syndrome and the relationship, provides the reference for the clinical treatment.Methods:collected from March2009to March2012at the Fuzhou general hospital kidney internal medicine inpatient concurrent renal biopsy pathology report for hepatitis B virus associated glomerulonephritis type IgA patients40cases observed in general, including patient name, gender, age, past medical history, family history, predisposing factors, clinical manifestation, pathological types, collection of laboratory index:mainly including blood pressure,24h quantity of urinary protein, serum creatinine, blood urea nitrogen, serum uric acid, plasma albumin and total protein, total cholesterol, Triglycerides, liver function, serum complement C3and C4, immunoglobulin IgA, IgG and IgM, two pairs of semi-hepatitis B using enzyme linked immunosorbent assay of serum HBsAg, HBsAb, HBeAg, HBeAb, HBcAb etc.. According to the2002" guiding principles of clinical research on new drugs of traditional Chinese medicine" in the relevant standards, the disease of syndrome differentiation, according to the characteristics of syndrome distribution of cases,40patients divided into yin deficiency of liver and kidney and non liver and kidney deficiency group, all the data for the application of SPSS16software to carry on statistical analysis.Results:in40patients,31were male,77.5%, the youngest is18years old, a maximum of44years, of which18to29years of most patients,87.5%patients with clear HBV infection history, clinical manifestations of nephritic syndrome accounted for57.5%, no obvious symptoms, urine routine examination found unusually,80%of patients without hepatitis B family history, two pairs of semi-hepatitis B is big Sangyang have the highest proportion,55.0%, small Sanyang accounted for37.5%. Pathological grading and WHO grade Ⅲ, Ⅳ, accounted for all histological types of95.0%, Oxford typing mesangial proliferation integral as M1accounted for the largest proportion,92.5%, there is no endocapillary proliferation each half, a segmental sclerosis or adhesion of the proportion is larger,87.5%, renal tubules atrophy or interstitial fibrosis in the proportion of0-25%proportion is large, there are70%. The main symptoms of traditional Chinese medicine in Yaoxisuanruan, lassitude, eye dryness or blurred vision, five upset hot, less gas is weak,dizziness and tinnitus, easy to catch cold, spontaneous or night sweats, floating face swollen limbs, dry pharynx dry etc.. The tongue in red and pink, with a thin yellow tongue coating and Bo Bai, pulse to fine, fine mainly string and string. Dialectical main card with Yin deficiency of liver and kidney syndrome, and permit mainly as damp-heat syndrome. Divided into liver and kidney yin deficiency and yin deficiency of liver and kidney group, statistical analysis showed liver and kidney yin deficiency group serum creatinine levels of liver and kidney yin deficiency group slightly lower, more than index was not statistically significant. In view of hepatitis B virus associated type IgA low incidence, this study incorporated the number of cases is relatively small, further expand the sample observation..Conclusion:1、Hepatitis B virus associated glomerulonephritis type IgA common in young male patients, hepatitis B virus infection in the pathogenesis of its important role.2、Pathological grading and WHO grade III, IV, pathological damage in severe, Oxford typing mesangial proliferation integral as Ml and segmental sclerosis or adhesion of the proportion of larger, tubular atrophy and interstitial fibrosis ratio in most of the0-25%range.3、The disease is most common symptoms of traditional Chinese medicine were Yaoxisuanruan, lassitude, eye dryness or blurred vision, five upset hot, less gas is weak, dizziness and tinnitus,easy to catch cold, spontaneous or night sweats, floating face swollen limbs, dry pharynx dry, red tongue, thin yellow tongue fur, pulse fine.4、TCM syndrome with Yin deficiency of liver and kidney syndrome of damp-heat, clip concurrently.