The Theoretical Discussion Of Chinese Herbaceous Peony’s Getting Rid Of Blood-Arthralgia And Its Observation Of Curative Effect In Treating Nephritis

ObjectiveChinese herbaceous peony is traditional Chinese Medicine which is common used in the clinical. Nowadays, most medical formulary record its effect as nourishing blood and liver, clearing away stagnate and relieving pain, and so on. But the effect of Chinese herbaceous peony that "Shen Nong’s Herbal Classic" says "getting rid of blood-arthralgia"(which is getting rid of wind-damp), is not received its corresponding value.This reserch make a systematic study to clear up and summerise much ancient literature in Traditional Chinese Medicine, and to review information of Chinese herbaceous peony’s getting rid of wind-damp in modern pharmacology study, which could provide theoretical reference for the clinical application and fuether reserch of Chinese herbaceous peony’s getting rid of wind-damp. At the same time, through this clinical study, to observe the effect and side effect of the Pafulin capsule (total glucosides of paeony capsule) on people that with chronic nephritis, and to confirmation the effect of total glucosides of paeony’s getting rid of wind-damp.MethodsThrough looking up ancient literature in Traditional Chinese Medicine, make extracts of the record of peony, including property and flavor, channel tropism, the major functions and clinical apply, to confirmation the effect of peony. Collect90patients who accord with the diagnosis of primary chronic nephritis, Glomerular Filtration Republic (GFR)>60ml/min·1.73m2,24hours’proteinruia<lg,moreover never used any immunosuppressor as objects, among whom60patients as the treatment group that use TGP,30patients as the matched group. Observe the Urine routine,24-hour urine protein quantitation, Creatinine Clearance Rate (Ccr), Glomerular Filtration Republic (GFR), Kidney function (Scr, BUN, UA), Albumin (Alb), Liver function, Blood routine of the patients before and after the treatment, as also record the side effect. As well as make Wind-Damp symptom integration of these patients before and after the treatment. Lastly, make objective evaluations of the effect of TGP on threating the patients with chronic nephritis.ResultsChinese herbaceous peony tastes bitter, little cold property, belong to liver and spleen channel. Through discussing the application in classical prescription and prescription that threat rheumatism in successive dynasties, and commbined by modern pharmacological research, the goal is to confirmation the effect of total glucosides of paeony’s getting rid of wind-damp.Through the clinical research, we can find that TGP could improve the Wind-Damp symptom integration for these patients.Compared with the matched group, the patients’ Wind-Damp symptom integration of the treatment group are much lower (P<0.01); Lower the urine protein quantitation and urine blood cell count (the treatment group P<0.01:the matched group P<0.05). The urine protein quantitation and urine blood cell count of the treatment group’s are lower than the matched group’s, but no significant difference is noted between them (P>0.05). In the group of TGP, the effect of longer course of treatment and high dose of treatment are much better than shorter course of treatment and less dose of treatment,there is significant difference between them(P<0.05,P<0.05). The side effect of TGP is not serious, appearing as loose stool, diarrhea, but could be improved by adjusting the dose of medicine.ConclusionFirstly, by the ancient-book reserch of Chinese herbaceous peony’s property and flavor,channel tropism, the major functions and clinical apply,as well combined with modern pharmacological reserch and the application in classical prescription and prescription that threat rheumatism in successive dynasties, confirm that Chinese herbaceous peony has the effect of getting rid of blood-arthralgia and getting rid of wind-damp.Secondly, TGP could obviously improve the Wind-Damp symptom integration for these patients. Could lower the urine protein quantitation and urine blood cell count, but the effect is weak, and also related to the service time and dose. The effect that threatment much longer and the dose much bigger is much better. The side effect of TGP is not serious, mostly appearing as diarrhea.Compareed with other immunosuppressor with more side effect, TGP is more easily accepted by patients, and is worth popularized useage in the clinic.