Polycystic Ovary Syndrome Of Insulin Resistance In Patients With Clinical Characteristics Analysis

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases ofwomen in childbearing age characterized by long-term ovulation dysfunction, menstrualdisorders, androgen excess and ovarian polycystic change,which incidences in puberty. It hasbeen reported by Burghen in 1980 for the first time since the PCOS patients havehyperinsulinemia, then more and more clinical evidences show that patients with PCOS haveprevalence of insulin resistance (IR), which plays an important role in the pathophysiology inPCOS incidence associated with long-term complications closely[1]. In this paper, according tothe 2003 Rotterdam International diagnostic criteria for diagnosis of PCOS,we observed clinicalfeatures of 92 cases of patients with polycystic ovary syndrome in the IR and non-insulinresistance (NIR) to provide the basis for the rational treatment for PCOS.Objective: To investigate the clinical features of polycystic ovary syndrome (PCOS)patients with insulin resistance and non-insulin resistance and find the correct diagnosis andproper treatment for PCOS.Methods: We compiled 92 cases From February 2010 to August 2011, the First Hospital ofShanxi Medical University, gynecological out-patient treatment and diagnosis of PCOS patientsa total of, medical records selected condition is not applied hormone drugs in all patients within3 months PCOS diagnostic criteria for the selection of the 2003 Rotterdam Internationaldiagnostic criteria, divided into 60 cases of insulin resistance by homeostasis model assessmentindex (HOMA), non-insulin-resistance of 32 cases. Measurement records of patients’age, height,weight, waist circumference, hip circumference, Ferriman-Gallwey (F-G) scoring, acne grading,body mass index (BMI) and waist hip rate, including BMI≥25kg/m2was obesity andWHR≥0.85 was abdominal obesity. Menstrual disorders (amenorrhea, oligomenorrhea,menstrual frequent); magnetic particles ELISA method was used for the determination ofserum luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estrogen(E2), progesterone (P), testosterone (T); the radioimmunoassay was used to measure fastinginsulin (FINS) and insulin release test (IRT); glucose oxidase to measure fasting plasma glucose(FPG) and oral glucose tolerance test (OGTT).We collected the information by SPSS17.0statistical software analysis.Results:1. Anthropometric index and obesity of patients in two groups: in 92 cases of patients ,60patients with IR, 32 patients with NIR. Waist circumference, hip circumference, waist to hip ratio and BMI were higher in IR groups than that of the NIR groups, and the difference wasstatistically significant (P<0.01). Obese patients in IR groups were 46 cases, and 16 cases ofnon-obese (39 cases of abdominal obesity); in the NIR groups,there were 11 cases of obesity,non-obese 21 cases (13 cases of abdominal obesity); obesity in IR groups accounted for 76.67%and accounted for 34.38% in NIR groups. The obesity rate of the IR groups was significantlyhigher than the NIR groups, and the difference was statistically significant (P<0.001).2. Two groups of patients had high performance of androgen: there were 27 cases ofandrogen , and in the IR groups there were 20 cases, seven cases in the NIR groups,which wasno statistically significant difference (P>0.05); FG scores and acne grading were also nosignificant difference (P>0.05).3. Comparison of blood glucose levels and insulin values between two groups: in IR groups,OGTT at each time point blood glucose levels and insulin levels of the IRT at each time pointwere higher than that of the NIR groups,and the difference was statistically significant (P<0.05);in IR groups, HOMA-IR, the ISI GAUC, IAUC, and GAUC/IAUC were significantly higherthan that of the NIR groups,and the difference was statistically significant (P<0.001).4. Comparison of serum sex hormones between two groups:in IR groups,LH / FSH waslower than that of NIR groups, and E2 was higher than that of the NIR groups, and the differencewas statistically significant (P<0.05).While the difference between LH, FSH, PRL, P and T wasno statistically significant (P>0.05) between two groups of patients.Conclusions: IR can promote PCOS obesity, especially the abdominal obesity, and is closelyassociated with disorder of glycometabolism. Early intervention has great importance to proventthe long-term complications in patients with PCOS.