Heat Material Side Treatment Of Obese Type 2 Diabetes Mellitus And Dyslipidemia (liver) Stomach Muggy Syndrome Subgroup Analysis Of Clinical Research

Objective:①We discussed the drug selection principles of MS treatment using symptoms-syndroms-diseases combined method which established by Professor Xiaolin Tong.②we discussed the characteristics of MS and the experience for clinical practice.③To observe the clinical efficacy of the Chinese medicine composing prescription (QingReJiangZhuoFang) in the treatment of type2diabetes mellitus combined hyperlipidemia (blood sugar, blood lipid, blood pressure,etc). To observe the effects of prescription on the other components of metabolic syndrome, the cardiovascular risk factors (weight, BMI, waist circumference) and traditional Chinese medical clinical symptoms.Methods:Two hundred fifty of overweight or fat primary diabetes mellitus (The Stagnated Heat Syndrome in the Liver and Stomach) cases were recruited, which were divided into2groups in a randomized, paralleled, contrast, multicentre prospective study. The patients in control group were treated with metformin tablets and in trial group were treated with Chinese medicine composing prescription(QingReJiangZhuoFang).The efficacy of the prescription were evaluated after treatment12weeks.Results:①Summary Professor Xiaolin Tong’s experiences of treating abnormal laboratory examination.What’s more, we exampled cases and analyzed them.②A total of109cases were included in statistics, including52cases treated,59patients in control group. General information, the main indicators level and TCM symptom scores has no significant difference in patients with baseline. After12months’ observation period, FBG、 P2BG、HbAlc of two groups were lower compared with before treatment(P<0.05).FBG,(1.60±2.69) mmol/L were lower compared in trial group and (0.80±1.85) mmol/L were lower compared in control group;P2BG,(4.65±4.42) mmol/L were lower in trial group and (3.40±3.23) mmol/L were lower compared in control group; HbAlc,(1.47±1.43)%were lower in trial group and(1.67±1.62)%were lower compared in control group; The differences in both groups were insignificant(P>0.05).TG、TC of two groups were lower compared with before treatment(P<0.05).LDL-C of two groups were lower compared with before treatment、HDL-C was higher compared with before treatment. The differences in both groups were insignificant(P>0.05). TG,(0.89±1.32)mmol/L were lower in trial group and (0.41±1.12) mmol/L were lower compared in control group; The differences in both groups were significant(P<0.05).TC,(0.22±0.96) mmol/L were lower in trial group and (0.23±0.69) mmol/L were lower compared in control group; The differences in both groups were insignificant(P>0.05).HDL-C,(0.01±0.28) mmol/L were higher in trial group and (0.09±0.83) mmol/L,were higher in control group; The differences in both groups were insignificant(P>0.05).SBP、DBP of both two groups were lower compared with before treatment(P<0.05).SBP,(11.28±12.55) mmHg were lower in trial group and (13.00±19.90) mmHg were lower compared in control group; DBP,(8.22±10.45) mmHg were lower in trial group and (10.50±13.94) mmHg were lower in control group; The differences in both groups were insignificant(P>0.05).HOMA-IR,(0.29±0.72) were lower in trial group and (0.18±0.60) were lower in control group; The differences in both groups were insignificant(P>0.05).HOMA-ISI,(1.53±2.82) were higher in trial group and (1.29±0.81) were higher in control group; The differences in both groups were insignificant(P>0.05).Weight、BMI and waist circumference(WC) of two groups were lower compared with before treatment(P<0.05).The differences in both groups were insignificant(P>0.05). The impact of the traditional Chinese clinical symptoms:the traditional Chinese clinical symptoms of two groups have been alleviated significantly after the treatment. The differences of the alleviation of irritability in both groups were significant while the other symptoms in both groups were insignificant.Conclusion:①we discussed the methods and rules to treat abnormal examination of MS with the symptoms-syndromes-diseases combined method.②The clinical trials results shows that the Chinese medicine composing prescription(QingReJiangZhuoFang) can lose weight and improve high blood sugar Dyslipidemia. high blood pressure、HOMA-IR of type2diabetes mellitus patients. The effect is identical with metformin. Also, the Chinese medicine composing prescription (QingReJiangZhuoFang) can control other components of metabolic syndrome and cardiovascular risk factors increasing, which can also improve the TCM clinical symptoms.