| Purpose：Chronic fatigue syndrome is a1988American disease control center wasofficially named, belongs to the category of sub-health. With the rapid development of socialeconomy,the incidence of CFS is increasing trend, CFS in twenty-first Century will be themain problems of human health. At present western medicine on CFS is no definitivetreatment method, but in recent years, Chinese medicine treatment of CFS play a uniqueadvantage, The mild moxibustion as no trauma, no toxic and side effects of a drug greentherapy, On the treatment of CFS with unique curative effect. In recent years, many clinicalreports have proved this point. The study of Mild Moxibustion" Guan yuan" acupoint onchronic fatigue behavior of rats and the serum ACHT (adrenocorticotropic hormone), CORT(cortisol) effect, Study of mild moxibustion on chronic fatigue syndrome therapeutic effect,for clinical treatment of chronic fatigue syndrome and provide experimental basis.Material and method：Clean SD female rats60, Each weight170g+10g, With musclegrouping into normal group, model group, ginseng saponin powder group, moxibustion Guanyuan acupoint group. Using cold water swimming and chronic restraint method, establishmentof a rat model. The normal group model group without treatment, after making model nottreated its natural restoration, the treatment group in the molding and treatment. Ginsengsaponin powder group given ginsenoside (70mg/kg/D) water solution lavage treatment;Guan yuan Acupoint Moxibustion group was given a mild moxibustion therapy, a total of21days; After the end of the experiment, the rats were observed for the general conditions andbehavioral changes; ELISA method for the determination of serum ACTH, CORT levels.Results：1.The general situation and the changes of behavior: Molding, rats drinking quantity, foodintake, body weight, stool and rat hair color, activity, with no obvious abnormalities, with themolding time, rats in the normal group, the amount of water intake, body weight, stool and rathair color, activity, with no obvious abnormalities; The rats in the model group, the waterquantity decrease of eating, weight loss and rat wool drop, lose luster, activity unresponsive, open field test of horizontal movement and vertical movement of the number of times weredecreased (P <0.05); The treatment group compared with the model group, the amount ofwater intake, weight and hair color, activity were normal, open field test of horizontalmovement and vertical movement of the number of times were increased (P <0.05). Thatforced swimming in the cold water plus chronic restraint replication of chronic fatigue ratmodel is feasible.2. The chronic fatigue rat ACTH, CORT effects: Compared with the normal group, modelgroup, ACTH, CORT was increased (P <0.05); the treatment group compared with themodel group, ACTH CORT significantly decreased (P <0.05).Conclusion：1. The experimental results show that, by swimming in cold water and make mold afterchronic restraint, Rat model appeared with human CFS similar to clinical manifestations, suchas rats, reduce the amount of drinking water intake, weight loss and rat wool drop, lose luster,activities such as slow performance, We confirmed using the replication of the CFS model issuccessful. Mild moxibustion acupoint Guan yuan compared with model group, the amount ofwater, food intake, body weight and hair color, activity were normal, mild moxibustionacupoint Guan yuan note improvement in a rat model of physical and emotional depression,irritability, can effectively adjust the body and the psychological state of fatigue.2. through the observation of the chronic fatigue rat serum ACTH, CORT content changes,found that the levels of these substances disorders associated with CFS development. Guanyuan acupoint mild moxibustion, CORT reduced ACTH content regulation, may be mildmoxibustion Guan yuan acupoint can regulate the CFS central nervous system function,regulation of the HPA axis function, improving the fatigue state, the mechanism of thetreatment of CFS. |
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