Ziyin Kidney In Treatment Of Kidney Yin Deficiency Type Of Clinical Study Of Male Infertility

BackgroundIn recent years, the number of male infertility patients showing a rising trend in the world, China’s relevant clinical research shows that the incidence of up to10%of infertile couples, which alone caused by man’s reason up to20%, plus both sides The reason males possession factor of50%.The etiology and pathogenesis of male infertility, traditional medicine and modern medicine has an associated elaborated:modern medicine on the causes of male infertility and pathogenesis is not yet entirely clear. About the cause of male infertility, it is now more comprehensive and recognized:a taxonomy, the World Health Organization (WHO),16; another men Sci ences Branch of the Chinese Medical Association to testicular boundaries before after and idiopathic four categories of classification. Research on the pathogenesis of male infertility, unfortunately,due to technical and research time (as opposed to other cardiovascular diseases) human male infertility can be described only in its infancy, to be able to put forward the view, various scholars hold views different emphasis can not be unified. Antioxidant (oxygen free radicals, nitric oxide, etc.); nutrition (lack of trace elements) endocrine and immune (autoimmune infertility, endocrine disorders); physical and chemical aspects of the (radiation, high temperature, chemical). Traditional Chinese medicine mainly from exogenous and internal injuries, impassioned,diet, congenital, acquired the cause of male infertility discusses comparative summary of the understanding of the pathogenesis of male infertility recognized by the majority of physicians recognize is " kidney "oriented, both liver depression, angry, phlegm, hot and humid, blood deficiency, blood stasis is marked, the combined effect of multiple risk factors.Chinese medicine for the treatment of male infertility is based diagnosis and treatment, the legislation more from warming yang, yin and kidney, etc. Bushentianjing proceed. Common prescription is more based on prescriptions from Pills Yin Sheng Shen Qi Wan ZuoguiWan five Yanzong, Yougui balls famous from the CD, part of the reports that some patients with semen quality improved to some extent, some couples successfully conceive.Yin deficiency of modern medicine, traditional Chinese medicine treatment for nourishing yin class research suggests its therapeutic mechanism may be:cases of damage caused by influencing allergy;②hypothalamic-pituitary-gonadal endocrine axis, thus affecting spermatogenesis mature peroxidation product;(3) the antioxidant role:superoxide dismutase, NADH dehydrogenase, H+-ATP enzyme activi ty, Clear to reduce the damage to sperm;④enhance its activities may gonads. PurposeZuo Gui Pill of objective evaluation of the efficacy of kidney yin deficiency in infertile men. MethodThrough investigat ion Dongzhimen Hospital of Beijing University of Traditional Chinese male outpatient visits in February2012to April2013in the age of the23-year-old to42-year-old semen of infertile patients conventional sex hormones five the TCM related syndromes group According to the World Health Organization male infertility standardized check with the clinic Manual and Guo Ying Lu, Hu liquan editor Andrology TCM clinical diagnosis and treatment of the term (the syndrome)"(State Bureau of Technical Supervision national standards GB/T16751.2-1997), and WESTERN, edited by Cheng Shiu Chi TCM diagnostics developed Western diagnostic cri teria, TCM standards and exclusion cri teria, at the Western diagnostic criteria, TCM criteria, exclusion criteria included in the61patients during the period and in accordance with the shedding standards, excluding standard decision whether or not to suspend the study of the patients included in the study, you can continue to researchers give Zuogui Pill formulations particle therapy and0-7days after the start of the study,30±5days,60±5days,90±5days, first off inspection and TCM syndrome score to assess the clinical evaluation of the efficacy of the standard formulation in accordance with the guiding principles of TCM new drug clinical research according to the World Health Organization male infertility standardized check with the clinic manual and reference.ResultIn this study, clinical total of61cases,ineffective in11cases, ineffective rate was18%; effective in32cases, an effective rate of52%;11cases markedly effective rate is18%,7cases cured, the cure rate is12%, the total effective cases50, with a total effective rate of82%; the patients semen volume, sperm concentration before and after treatment, the difference was statistically significant (P<0.001);patients before the difference was statistically significant (P<0.05) before and after treatment to the percentage of motile sperm, sperm The total survival rate, total sperm count before and after treatment the difference was very significant, statistically significant (P<0.00]), the difference was not significant forward movement A sperm before and after treatment, was not statistically significant (P>0.05). Found the liquefied semen before and after the treatment before and after treatment hormone five checks patients also found a statistic ally significant difference (P<0.05); E2, FSH, LH before treatment after treatment, the difference was statistically significant (P<0.05), T therapy The difference was statistically significant (P<0.01) after treatment before of PRL before treatment, after treatment, the difference was not statistically significant (P>0.05).TCM Syndrome aspects study also found that patients Yaoxi suanruan five upset, hot, tinnitus, dry mouth and throat, hot flashes,night sweats, Gu Zheng, hot flashes, red tongue, little coating, rapid pulse points and score points before treatment after treatment The difference was statistically significant (P<0.01).Description the Pill Zuogui effective in improving the main symptoms of Yin deficiency male infertility patients baking.ConclusionZuo Gui Pill in Yin deficiency male infertility patients on the treatment, can increase the amount of semen, sperm concentration, total sperm activity rate, improve semen liquefied state, and no significant forward movement Class A sperm improve; that, elevate the male infertility serum testosterone level (T), lower serum estradiol (E2), influence serum FSH levels affect the level of serum luteinizing luteinizing hormone (LH), and in patients with low serum prolactin levels had no significant effect; waist and knees in improving kidney yin deficiency syndrome patients with male inferti lity, five upset hot, tinnitus, dry mouth and throat, hot flashes, night sweats, Gu Zheng, hot flashes, red tongue, little coating, rapid pulse main symptoms.