Study Of Preparation Technology、Stability And Anti-inflammatory Effects On Balamcanda Chinensis Throat Tablets

Balamcanda Chinensis throat tablets, is based on professor liu or just Balamcanda Chinensis throat tablets best extraction and preparation technology of the preparation. By Balamcanda Chinensis, Sterculia lychnophora, prepermint oil,and the mount of xylitol.Has remove the heat and Remove poisonous gas, eliminate sputum pharynx of function, can be used to treat sore throats, phlegm fire within, cough asthma, etc. This paper summarizes the characteristics of main medicine, for the formulation and the influence factors of stability and long-term study on system stability and pharmacological effects.一、preparation technology was studiedBalamcanda Chinensis extraction technology by6times the concentration of70%ethanol to correlation of effective components of ethanol extraction, extraction of3times, each time1.5h. The extraction process of Sterculia lychnophora is material liquid than1:30, extraction temperature controlled at80℃, the extraction time was0.5h. Bonding with90%ethanol extract to Balamcanda Chinensis and Sterculia lychnophora powder, and add a certain amount of peppermint oil and xylitol, and carries on the tablet, put in the dryer. Set aside.二、Factors affecting stability and long term stability studyWill Balamcanda Chinensis throat tablet, respectively, under the condition of high temperature, high humidity, strong illumination, respectively0d,5d,10d time, using the thin layer correlation irises in dry times flavin identification study, high performance liquid chromatography (HPLC) determination of time iris flavin content research, test and other related factors, all the indexes accord with the stability of Chinese medicine, natural medicine research technical guiding principles. Will Balamcanda Chinensis throat tablet placed at room temperature, respectively, in3,6,9,12,18months, searched for related factors, the moisture absorption rate, content is relatively stable.三、Balamcanda Chinensis throat tablet for chronic pharyngitis Japanese big ear rabbit model of pharyngeal pathological morphology researchIn24rabbits were randomized, divided into model group, HuaSu tablet group, high dose group, middle dose group, low dose group and blank group, with ammonia and turpentine made mould for15days pharyngitis (except the blank group). Building after a successful HuaSu group of dosing HuaSu pills, daub distilled water blank group, other groups for Balamcanda Chinensis throat tablet, continuous medication for10days. Observation of shoot dry throat lozenges on experimental chronic pharyngitis rabbit’s general condition, body temperature and white blood cells (WBC) count, neutrophil percentage (N), lymphocyte percentage (L)(M) and monocyte percentage, etc. Enzyme linked immunosorbent test on rabbit vascular cell adhesion factor1(VCAM1), tumor necrosis factor alpha (TNF alpha) changes of cytokines and so on. Results showed that the HuaSu tablet group, the high, medium and low dose group of symptoms of chronic pharyngitis rabbit all have different degrees of improvement, including HuaSu group, high dose group and middle dose effect is best. Of the general conditions improved, it not only makes the rabbit and the rabbit rise in body temperature and white blood cell (WBC), lymphocyte percentage (L), monocyte percentage (M) is reduced, to reduce the height, weight, percentage of neutrophils (N); Pharyngeal pathological morphology improved, inflammatory cells infiltration, swelling significantly reduced or even disappear; At the same time reduce the vascular cell adhesion factor1 (VCAM1), tumor necrosis factor alpha levels (TNF alpha). Shoot dry throat lozenges has qingrejiedu, eliminate sputum pharynx of function, can be used to treat sore throats, phlegm fire within, cough, asthma disease salivary indicates, hoarseness. Has a better therapeutic effect to chronic pharyngitis, chronic pharyngitis provides scientific basis for clinical treatment and valuable reference.