| Pharmaceutical analysis technique is the foundation of assure humanhealth and life safety. Electrochemical method, as a novel and highly sensitiveanalytical technique for medicine analysis, performed some goodcharacteristic，such as fast analytical speed, simple instrumentation and lowcost．Chemically modified electrode is investigated very actively in thecurrent research field of electroanalytical chemistry,and its application is veryextensive． Recently, application of chemical modified electrode in thepharmaceuticals analysis in recent years has been made great progress．Inthis work, Functional Carbon Nanotubes Composite Modified Electrodeswere applied to the determination of some drug molecules．The majorcontents are described as follows：（1）Poly-ascorbic acid functional multi-walled carbon nanotubescomposite modified electrode was prepared by electrochemicalpolymerization ascorbic acid on multi-walled carbon nanotubes modifiedglassy carbon electrode, this electrode was characterized withelectrochemistry methods and SEM,the electrochemical behavior of adenineon this electrode was studied.The results showed that this electrode exhibitedexcellent electrocatalytic effects to adenine, The oxidation peak currentchange linearly with the concentration of adenine from5.0×10-6mol/L to1.0×10-4mol/L. The detection limit was5.0×10-7mol/L，the recovery ratewas from96.0%to106.0%. The composite modified electrode wassuccessfully applied to the determination of adenine in Addition solutionMAP for storage red cell concentaytes.（2）A multi-walled carbon nanotubes（MWNTs）/Prussian blue（BP）composite modified glass carbon electrode（MWNTs/PB/GCE） was fabricated,Firstly, Prussian blue was modified on the surface of glass carbon electrode（GCE）by electronic chemistry deposition, then modified PB/GCE withMWNTs. The characteristic of the modified electrode was characterized by cyclic voltammetry. The modified electrode exhibited excellentelectrocatalytic effect and selectivity on the redox of dopamine （DA）. Whenthe same concentration of ascorbic acid （AA） and DA simultaneously exist insolution, AA has no interference to the determination of DA. Under theoptimum condition, the oxidation peak currents are in linear relationship withDA concentration in the range from5.0×10-6mol/L to1.0×10-4mol/L.Becauseof the low detection limit (cmin=5.0×10-7mol/L), and the high sensitivity forthe detection of DA （recovery rate between97.0%105.7%）, this modifiedelectrode can be used for quantitative determination of hydrochloricdopamine in injection samples.（3） Poly-vitamin B1/Ionic liquids/multi-walled carbon nanotubescomposite film modified electrode （PVB1/IL/MWCNTs/GCE） was prepared.The conditions of electrochemical polymerization of vitaminB1and theelectrochemical properties of PVB1/IL/MWCNTs/GCE were investigated.Studied the electrochemical behavior of tinidazole onPVB1/IL/MWCNTs/GCE, and a method of detecting tinidazole wasdeveloped. The reduction peak current of tinidazole is proportional to itssquare root of concentration from2.0×10-7mol/L to1.0×10-4mol/L, Thedetection limit is5.0×10-8mol/L.The recovery rate is from96.0%to106.0%.this modified electrode can be used for quantitative determination oftinidazole in tablet. |
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