Effects Of Infusion Of Dexmedetomidine In Different Periods On Anesthesia Wake Quality Of Neurosurgery Operation

Objective: To investigate the effects of infusion of dexmedetomidine inpreoperative, intraoperative and postoperative periods onanesthesia wake quality of neurosurgery operation.Methods: Choose80cases of neurosurgery operation patients, ASA GradeⅠ to Grade Ⅱ, age31to68years of age, body weight47to72kg.80patients were randomly divided into four groups (n=20): preoperativeInfusion of dexmedetomidine group (Group Ⅰ), intraoperative infusion ofdexmede-tomidine group (Group Ⅱ), postoperative infusion ofdexmedetomidine group (Group Ⅲ) and control group (Group Ⅳ).Group Ⅰadministered dexmedetomidine0.6μ g/kg (10min pump)30min beforeinduction of anesthesia; Group Ⅱ and Group Ⅲ respectivelyadministered dexmede-tomidine0.6μ g/kg (10min pump) at30min afteroperation and30min before the end of the operation; Group Ⅳadministered same volume of salt water. Before induction ofanesthesia(T0),the immediate extubation (T1),5min after extubation (T2),10min (T3),15min (T4),30min (T5),60min (T6), HR, MAP, SpO2and Ramsaysedation score were recorded, and record the time from the end of sutureto extubation, and VAS score, nausea and vomiting, patients withbradycardia, respiratory inhibition1h after extubation.Results: There was no significant difference in four groups of patientsof age and weight and operation time(P>0.05); compared with Group Ⅰ,GroupⅡ had no significant difference in HR,MAP, Ramsay sedation scoreat each time point (P>0.05), Group Ⅲ was significantly lower in HR atT1~T5, Group Ⅳ was significantly increased at T1~T6, the differencewas statistically significant (P<0.05); Group Ⅲ was significantlylower at T1~T6in MAP, Group Ⅳ was signifycantly increased at T1~T6,the difference was statistically significant (P<0.05); the sedation depth of Group Ⅲ was increased at T1~T6, Group Ⅳ was significantly deepat T1~T4, the difference was statistically significant (P<0.05); comparedwith Group Ⅰ, the extubation time of Group Ⅲ was significantly delaye,the difference was statistically significant (P<0.05); There was nosignificant difference in Group Ⅱ and Group Ⅳ(P>0.05); the SpO2ateach time point, VAS score and the adverse reactions of each group hadno significant difference (P>0.05).Conclusions:Infusion of dexmedetomidine perioperative can reduce stressreaction of tracheal extubation of craniotomy operation in anesthesiarecovery period, no significant adverse effects such as nausea andvomiting,inhibition of respiration，but prolong the extubation time inpostoperative periods, application preoperative and intraoperative ispreferred.