| Objective:1. To analyze the distribution of common allergens in patients with allergic rhinitisin Zhuhai area, explore the related risk factors of allergic rhinitis, provide ascientific basis for the diagnosis, treatment and prevention of allergic rhinitis.2. To analyze the clinical application value of serum specific IgE and skin prick test,and the relationship between two allergens methods. Select the better allergendetection methods for AR patients.Methods:1. From Apr.2012to Mar.2009,1986cases suspected with allergic rhinitis by thedoctor of ENT clinic in the Zhuhai Affiliated Hospital of Jinan University, wereenrolled in the project. Using the serum specific IgE detection methods,10common inhalant allergens were detected in AR patients, and the characteristicsof Inhaled allergens were analyzed in the distribution, number of differentallergens, and the relationship between allergens and the gender, age and visitingtime of patients.2.289cases with dust mite allergen were selected to perform the standardizationskin prick test using the ALK allergen reagents. These two detection methodsresults were compared. A detailed questionnaire survey was conducted in thesepatients to collect the clinical symptom score and related information. The relatedrisk factors causing allergic rhinitis were analyzed. Comparation of therelationship between the two detection methods was conducted in the results andtheir clinical symptom scores, and clinical relevances. Result:1. The ELISA data showed that1556cases were positive in1986patients, totalpositive rate was78.35%(1556/1986),positive rates of allergens were as follows:dust mite (52.8%), dog(43.2%), cat(30.4%), ragweed (23.2%), mugwort (16.3%),cockroach (14.4%), humulus lupulus (10.8%), mold (9.5%), Chinese parasol(6.8%) and elm (5.6%).2. In1986patients,1178cases were male, the positive cases were920, the totalpositive rate was78.1%(920/1178);808cases were female, the positive caseswere636, the total positive rate was78.7%(636/808). There was no statisticalsignificance difference in male or female groups(Χ~2=2.000，P=0.157). There wasno statistical significance difference in allergens of male and female groups(P<0.05).3. The number of visits in July, August and November was more than that in othermonths in a year. There were no statistically significant differences among thepositive rate of allergen in each month (Χ~2=132.000，P=0.233). There werestatistically significant difference among the positive rate of different allergens ineach month (P<0.05).4. Consistent positive diagnostic rate of6allergens (both of the two methods are allpositive and negative number/the number of detection) is higher. It were reached66.44%to95.16%..Except the dogs, the positive rate of other5allergens werehad statistically significant difference（sP<0.05). The serum specific IgE detectionrate of dust mites (Dermatophagoides pteronyssinus and Dermatophagoidesfarinae）, cats is higher than the skin prick test detection rate, the serum specificIgE detection rate of cockroach and mold are below those in the skin prick test.The consistency analysis of the two detection methods which about the6kindsallergen sample level comparison testing showed consistency of the two detectionmethods was low,the value of coefficient of rank correlation was-0.052to0.383,and the value of Kappa was-0.012to0.165.5. There were no significant correlation between the clinical symptoms of AR andthe SPT results about the positive strength of the Dermatophagoides pteronyssinus and Dermatophagoides farinae(Dermatophagoides pteronyssinus: r=0.047; Dermatophagoides farinae: r=0.102). There were no significantcorrelation between the clinical symptoms of AR and the SPT results about thepositive number of the allergen(r=0.120). There were no significant correlationbetween the clinical symptoms of AR and the ELISA results about the positivestrength of the dust mite (Dermatophagoides pteronyssinus andDermatophagoides farinae）(r=0.223). There were no significant correlationbetween the clinical symptoms of AR and the ELISA results about the positivenumber of the allergen (r=0.098).6. In289AR patients, there were119cases with allergic diseases in their family,occupy41.18%(119/289);41cases with Smoking history, occupy14.19%(41/289);154cases with exposing to the family smoking environment, occupy53.28%(154/289);249cases with living in the room using air-condition, occupy83.74%(249/289);61cases with feeding animals at home, occupy21.11%(61/289);242cases with using mattress in the bedroom, occupy83.74%(242/289);217cases with living in9floor below or bungalow, occupy75.09%(217/289);196cases with living in the building floor age older than10years,occupy67.82%(196/289) and57cases with family decoration or purchasingfurniture within a year, occupy19.72%(57/289).Conclusion:1. The positive rate of the aeroallergen which Using the serum specific IgEdetection method was rather high in the people which suspected with allergicrhinitis by the doctor. The positive rate was as follow: dust mite, dog, cat,ragweed, mugwort, cockroach, humulus japonicus, mold, Chinese parasol andelm. Most patients were had4or less positive allergens.2. There was no correlation between the positive rate of allergen and the sex or thevisiting month of patients. There was no correlation between the positive rate ofdifferent allergens and the sex of patients. But it had a relationship with thevisiting month of the patients. 3. The positive rate of two detection methods was rather high, and the consistencyof positive rate was good. But the consistency analysis of two detection methodswhich about the allergen level compare was low. So these two detection methodsshould be used comprehensively to obtain a better reliable result.4. There was no reaction between the severity of the AR symptoms and the twodetection methods results about the positive strength and the positive number ofthe allergens.5. The family history, living environment, feeding animals and smoking historywere the related risk factors of the AR. |
PDF Full Text Request