Effects Of Fermented Ginseng On Hyperglycemia In Alloxan-Induced Diabetic Mice

Objective:To investigate antidiabetic effects of fermented ginseng (FG)and its possible mechanism.Methods:Total100healthy kunming male mice,which weighted in (20±2) g, were randomly divided into normal control group (n=12)after normal feeding for3days. The other mice were given ip Alloxan (220mg/kg), when blood glucose between11. lmmol/L and26.lmmol/L were assigned to alloxan-induced diabetic mice established successful. After then according to the weight and blood glucose, alloxan-induced diabetic mice were divided into five groups:high-dose FG group (n=12), low-dose FG group (n=12), white ginseng(WG)group(n=12), Glipizide group(n=12), diabetes mellitus(DM)group(n=12).After i. g. medication for14days, blood glucose, TG, TC, T-SOD, MDA and1insulin levels were tested. As the last step in experiment analysed all data by SPSS17.0software. The measurement data expressed by x±s.The interclass discrepancy compared by Variance analysis method. The significance expresses by P value:when P<.0.05was significant; when P<0.01was very significant.Results:1. Effect of FG on weight in Alloxan-induced Diabetic MiceThe weight of mice in high-dose FG group and low-dose FG group were significantly higher than the DM group (P<0.01), while there was no significantly difference in WG group and Glipizide group (P>0.05)2. Effect of FG on Blood Glucose in Alloxan-induced Diabetic MiceThe blood glucose level in high-dose FG group、WG group、Glipizide group were decreased significantly compared with DM group (P<0.01), while there was no significantly difference in low-dose FG group (P>0.05); The blood glucose level in WG group、Glipizide group had no significantly difference compared with high-dose FG group (P>0.05)3. Effect of FG on TG in Alloxan-induced Diabetic MiceThe TG level in low-dose FG group、high-dose FG group、WG group、 Glipizide group were higher than the DM group,but not significantly (P>0.05).4. Effect of FG on T-CHO in Alloxan-induced Diabetic MiceThe T-CHO level in low-dose FG group、high-dose FG group、 WG group、 were higher than the DM group,but not significantly (P>0.05).5. Effect of FG on T-SOD in Alloxan-induced Diabetic MiceThe T-SOD level in low-dose FG group、high-dose FG group、WG group、 Glipizide group were significantly higher than DM group(P<0.01); The T-SOD level in low-dose FG group were decreased significantly compared with high-dose FG group (P<0.01), while there was no significantly difference in WG group and Glipizide group (P>0.05).6. Effect of FG on MDA in Alloxan-induced Diabetic MiceThe MDA level in high-dose FG group、WG group、Glipizide group were decreased significantly compared with DM group(P<0.01); The MDA level in Normal control group、low-dose FG group、WG group、Glipizide group were significantly higher than high-dose FG group(P<0.01).7. Effect of FG on INS in Alloxan-induced Diabetic MiceThe INS level in low-dose FG group、high-dose FG group、WG group、 Glipizide group were significantly higher than the DM group(P<0.01); The INS level in WG group、 Glipizide group were decreased significantly compared with high-dose FG group(<0.01)Conclusions:1. Fermented ginseng (FG) has antidiabetic effects.2. The antidiabetic effects of Fermented ginseng (FG) may be related to the antioxidation effects of Fermented ginseng (FG).