The Correlation Between Total Cholesterol, Low Density Lipoprotein Cholestorol And Hematoma Growth In Patients With Acute Intracerebral Hemorrhage

ObjectiveTo investigate the correlation between the levels of serum total cholesterol (TC), lowdensity lipoprotein cholestorol (LDL-C), and hematoma growth in patients with acuteintracerebral hemorrhage.Methods1. According to the matched criteria and exclusion criteria, we recruited144caseswith acute intracerebral hemorrhage（ICH）in this study who hospitalized inneurology ward after visiting Emergency Department from December2010toJanuary2013.2. A general statistical analysis was held on all research subjects in hematoma growthgroup and control group.3. After admission, measurement of the cases’ blood pressure were undertaken bymanual hemomanometer immediately, then which were assessed by NIHSS scores,the patients whose scores distribute from1to20were included in this study.4. After admission, all patients were identified as supratentorial hemorrhage(including putamen, lobe of brain, thalamic hemorrhage) by brain computedtomography (CT) within6hours,24hours after admission head CT scan wereperformed again, to measure and count the volume of hematoma according to tadaformula. Hematoma growth was characterized by volume of hematoma which increased by33%in the second CT examination. There were72patients inhematoma growth group (51male and21female cases), there were72patients incontrol group (52male and20female cases).5.5ml of venous blood was collected from the patients in hematoma growth groupand control group within6hours after incidence, and then it was sent to the testingcenter of our hospital, to detect blood glucose levels by GOD method, measure TCvalues by CHOD-PAP method, and measure LDL-C values by SUR method, usingautomatic biochemistry analyzer.6. Clinical data of the2groups were compared, and then statistical analysis wasconducted for the influencing factors of hematoma growth.Result1. There was no significant difference in gender distribution in the2groups（P＞0.05）.2. There were no significant differences in HIHSS scores and initial amount ofbleeding in the2groups（P＞0.05）.3. In hematoma growth group, the average age was62.74±10.14years old, systolicpressure:177.06±25.31mmHg, diastolic pressure:103.83±14.52mmHg, BloodGlucose:8.06±4.94mmol/L, which were significantly higher than those in controlgroup (p<0.05).4. In hematoma growth group, TC values:3.78±0.62mmol/L, LDL-C：2.10±0.47mmol/L, which were significantly lower than those in controlgroup(p<0.05).5. Variables assessed by Logistic regression model analysis were:LDL-C(OR=0.001,95%CI:0.001-0.024,p<0.001),TC(OR=0.057,95%CI:0.004-0.863,p=0.0322),blood glucose (OR=1.851,95%CI:1.219-2.810,p=0.0038), systolic pressure (OR=1.120,95%CI:1.021-1.229,p=0.0165),diastolic pressure(OR=1.152,95%CI:1.052-1.262,p=0.0023).ConclusionThe factors influencing hematoma growth in patients with acute intracerebralhemorrhage included systolic pressure, diastolic pressure, blood glucose, TC,LDL-C,and the most important factors are TC,LDL-C, so there was a negative correlationbetween TC, LDL-C and hematoma growth in patients with acute intracerebralhemorrhage.