The Study On Chemical Constituents Of Crepis Tectorum Linn

Crepis tectorum Linn. is a plant of Crepis species of Asteraceae. Commonly known asthe wugencao. A year or perennial herbs. Consists of twenty-five species in China, is found invarious places, mainly distributed in northeast, north China, northwest, southwest. The herbalis bitter taste, micro cold and commonly used in folk. It can relief of coughs and treatment ofasthma. Widely used in the treatment of respiratory diseases.The research object of this experiment is the roots of Crepis tectorum Linn. inHeilongjiang area. With the purpose of to extract medicinal chemistry composition. Thisexperiment is through the method of crystallization and chromatography. Separation andpurification obtained21kinds of compounds from the extracts of petroleum ether, the extractsof ethyl acetate and the extracts of n-butanol. Through the detection technology of IR,UV andNMR (¹H NMR,¹³C NMR) to determine the structure of compounds. This experiment extract7kinds of compounds for the first time from the roots of Crepis tectorum Linn.Thecompoundes Friedelin（1）, α-amyrin（2）, β-amyrin（3）, Tetracosanol（7）, Luteolin（12）,Chlorogenic acid（16）, Apigenn（17） were isolated from the roots of Crepis tectorumLinn..In the extract of petroleum ether, the content of triterpenoid compounds is3.61‰, thecontent of grease compounds is3.31‰, the content of sterol compounds is1.01‰.In theextract of ethyl acetate, the content of triterpenoid compounds is1.62‰, the content of sterolcompounds is0.44‰, the content of organic acid compound is0.11‰, the content ofcoumarin compounds is1.43‰. In the extract of n-butanol, the content of glycosidecompounds is3.73‰.