Clinical Trial Of Intra-operative Hyperthermic Intraperitoneal Chemotherapy For Advanced Gastrointestinal Cancer

Objective: To explore the efficacy and safety of intraoperative peritonealhyperthermo-chemotherapy combined with general venous chemotherapy on the middleand advanced gastrointestinal cancer. Methods: The clinical data of50cases of â…¡ to â…£stage patients with gastrointestinal cancer, admitted to the Fifth Affiliated Hospital ofXinjiang Medical from June2005to December2011, were collected and analyzedretrospectively and divided into two groups: intraoperative peritoneal hyperthermo-chemotherapy combined with general venous chemotherapy group (A group),23cases,including16cases of gastric cancer and7cases of colorectal cancer; simple postoperativeintravenous chemotherapy group (B group),27cases, including20cases of gastric cancerand7cases of colorectal cancer. The age, gender, lymph node metastasis, histological type,clinical stage, overall survival(OS), postoperative clinical and blood monitoring indicatorsbefore intravenous chemotherapy, systemic adverse reactions, the incidence of complica-tions were analyzed by Chi-square test or Fisher exact test. Survival rate was calculated byapplying Kaplan-Meier and Log-Rank test. Results: In this study, there are notsignificantly different with repect to age, gender, lymph node metastasis, histological type,and clinical stage,(P>0.05). Complete follow up data were obtained in47cases, themedian follow-up time was39months, Kaplan-Meier analysis showed OS of two groupwere different statistically, Log-Rank test showed there is significantly different betweentwo groups,(P<0.05). There is not significantly different in incidence of adverse reactionsbetween two groups, and performance of major adverse events were gastrointestinalreactions, bone marrow suppression, peripheral neurotoxicity and liver injury. Conclusion:Intraoperative peritoneal hyperthermo-chemotherapy combined with general venous chemotherapy improved overall survival in the comprehensive treatment of advancedgastrointestinal tumors and did not increase the adverse reaction of chemotherapy. That isa desirable treatment measures worthy of continued study.