| Objective: Discuss the function of short peptide formula milk in thecritically ill newborn on the early nutrition support, for establishing areasonable nutrition strategy about critically ill neonate.Methods: Patients infants, conforming to the standard of critically illneonate by PCIS, who were hospitalized in neonatal intensive care unit fromJanuary2012to December within their first72hours, were randomlyassigned to control group (formula0, the whole protein formula feeding, SPF)and experimental group (formula1, short peptide formula feeding, HPF),which were analyzed respectively by term and premature infant. The way offeeding conformed to the guidelines of clinical application of nutritionsupport in critical neonates in China, and can be adjusted according theindividual state. During the experimental period all the objects’ generalinformation were collected, enteral feeding situations, for example, milksupply, protein and calorie intake were recorded daily, and the weight weremeasured every other day early in the morning, similarly, head circumference and height were also measured every week in the morning. Fasting bloodwere collected for testing of blood biochemical indices in biochemistrylaboratory on the first, seventh, fourteenth and twenty-first day morningrespectively. Additionally, the levels of total bilirubin were monitored, andcomplications were also recorded.Results:(1) Growth aspects: there were no statistically differences among thegrowth rate of head circumference, height and weight, and weight recoverytime. But weight loss degree, compared with SPF group, were obvious lighter,which has remarkable significant difference (P＜0.05).(2) Protein aspects:there were no statistically differences between plasma total proteinconcentration and albumin on the first, seventh, fourteenth and twenty-firstday(P＞0.05). Identically, there were no remarkable difference between HPFgroup and SPF group on plasma prealbumin concentration during theprevious two weeks(P＞0.05). However, at the end of the third week, theconcentration of prealbumin,whether premature or term neonate, werehigher in HPF group than that in SPF group, which had statisticalsignificance (P＞0.05).(3) Biliribim metabolism aspects: the level of serumtotal biliribim of formula1in premature infants were lower than these of formula0on seventh day[(128.58±71.37)ummol/L VS (179.18±49.83)ummol/L](P＜0.05).And the duration of biliribim of formula1inpremature were also shorter than that of formula0[(5±2.43)d VS (7.23±1.99)d](P＜0.05). But the above situation were not discovered in termneonate of group HPF nor SPF.(4) Enteral feeding aspects: there were nosignificant difference with regard to the time of achieving totally enteralnutrition, the incidence of gastric retention, and the time of mecniumturning yellow between group HPF and SPF (P＞0.05). But the duration ofgastric rentention was shorter in group HPF about premature, compared togroup SPF premature, there had statistically difference (P＜0.05).(5) Therewere no significant differences among the level of serum calcium,phosphorous, alkaline phosphatase, urea nitrogen, creatinine(P＞0.05). Andthe incidence of necrotizing enterocolitis, cholestasis, hypocalcaemia had nostatistically differences neither(P＞0.05)Conclusion:(1) Short-peptide formula may be benefical to the weightgovernment, which can lessen the weight loss degree, and has advantage ofgrowth chase.(2) Short–peptide formula is probably better than the whole protein formula about the metabolism of biliribim and duration of jauadicereduce.(3)Short–peptide formula may be more suitable for keepinggrastrointestinal function in critically ill,to a better nutrition state. |
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