Clinical Significance Of CEA、CA125、CA19-9and AFP Serum Levels In Diagnosis Of Gastrointestinal Cancer

Objective：To investigate the clinical significance of elevated serum CEA、CA125、CA199and AFP levels in the diagnosis of gastrointestinal cancer.Methods：Retrospective analysis serum levels and positive rate of CEA, CA125,CA19-9and AFP in371patients with colorectal cancer，185patients with gastric cancerand210patients with chronic gastritis were diagnosed by pathology，which fromJanuary2012to December2012at the First Affiliated Hospital of Dalian MedicalUniversity.Results：1. The positive rate of CEA, CA125, CA19-9and AFP in patients withcolorectal cancer were43.9%,6.2%,21.8%and3.5%，respectively. The positive rate ofCEA, CA125and CA19-9in patients with colorectal cancer were higher than that ofpatients with chronic gastritis(P<0.05). The positive rate of AFP was no significantdifference in colorectal cancer and chronic gastritis(P>0.05).The positive rate of CEA,CA125, CA19-9and AFP in patients with gastric cancer were20%,5.9%,17.3%and7.6%，respectively. The positive rate of CEA, CA125, CA19-9and AFP in patients withcolorectal cancer were higher than that of patients with chronic gastritis(P<0.05).Thepositive rate of CEA in colorectal cancer higher than in gastric cancer，but the positiverate of AFP in gastric cancer higher than colorectal cancer(P<0.05). The positive rate ofCA125and CA19-9were no significant difference in colorectal cancer and gastriccancer(P<0.05).2. Each level section of the proportion of CEA in colorectal cancer higher than in gastriccancer(P <0.05). Each level section of the proportion of CA125and CA19-9were nosignificant difference in colorectal cancer and gastric cancer(P<0.05). The level sectionof the proportion of AFP rose more than4times in gastric cancer higher than in colorectal cancer, there was no significant difference in the rest of the same level(P>0.05).3. The positive rate of CEA in colorectal cancer of poorly differentiated group,moderately differentiated group and well-differentiated group compared with each otherwere significant(P<0.05). The positive rate of CA125, CA19-9in colorectal cancer ofpoorly differentiated group were higher than well-moderate differentiatedgroup(P<0.05).4. In colorectal cancer, the level section of the proportion of CEA rose more than4times in poorly differentiated group, moderately differentiated group andwell-differentiated group compared with each other were significant(P<0.05). The levelsection of the proportion of CA19-9rose more than4times in poorly differentiatedgroup higher than well-moderate differentiated group(P<0.05).5. In colorectal cancer, the positive rate of serum CEA in stage Dukes A, stage Dukes B,stage Dukes C and stage Dukes D was7.1%,43.3%,43%and75%respectively. Thepositive rate of serum CEA in stage Dukes D was higher than that in the otherstages(P<0.05). The positive rate of serum CA125in stage Dukes A, stage Dukes B,stage Dukes C and stage Dukes D was0,6%,3.3%and20%, respectively. The positiverate of serum CA125in stage Dukes D was higher than that in the other stages(P<0.05).The positive rate of serum CA19-9in stage Dukes A, stage Dukes B, stage Dukes C andstage Dukes D was3.6%,15.9%,25.6%and50%respectively. The positive rate ofserum CA19-9in stage Dukes D was higher than that in the other stages(P<0.05).6. In colorectal cancer, the level section of the proportion of serum CEA rose more than4times in stage Dukes D higher than that in stage Dukes A, stage Dukes B and stageDukes C(P<0.05). The level section of the proportion of serum CA19-9rose more than4times in stage Dukes D higher than that in stage Dukes A, stage Dukes B and stageDukes C (P<0.05).7. In gastric cancer, the positive rate of CEA in poorly differentiated group higher thanthat of well-moderate differentiated group(P<0.05). The positive rate of CA125,CA19-9and AFP compared in different degrees of differentiation was no significantdifference(P>0.05).8. In gastric cancer, each level section of the proportion of CEA, CA125, CA19-9andAFP in different degrees of differentiation were no significant difference(P>0.05).9. In gastric cancer, the positive rate of CEA, CA125and CA19-9in patients with lymph node and distant metastasis higher than that of patients without lymph node anddistant metastasis (P<0.05).10. In gastric cancer, the level section of the proportion of CEA, CA19-9rose more than4times in patients with lymph node and distant metastasis higher than that of patientswithout lymph node and distant metastasis (P<0.05).Conclusions：1.The CEA have a certain value of diagnosis in colorectal cancer,gastric cancer, but the positive rate is not high.2.Serum levels of CEA, CA19-9and CA125can be increased at different degree incolorectal cancer and gastric cancer, the low-level rises should also attach importance.3.Elevated serum levels of CEA and CA19-9may helpful to determing the stage andprognostic in colorectal cancer and gastric cancer.