The Mechanism, Similarities And Differences Of Blood Lipid Reduction After Different Types Of Carbohydrates Intake

The purpose of this study is to provide further confirmation that digestion-resistant dextrin, slowly digestible starch and sugar substitute sweeteners can lower blood lipid and glucose levels which are both chronic disease indicators, through a scientific study with animal tests, thereby relevant concepts may be popularized effectively, applications be boosted, current diet of the population be improved and balanced, and incidence of chronic diseases be further reduced.In the established mouse models of acute hyperlipidemia, regulation and control of a variety of carbohydrates and starch derivatives on blood lipid was observed and logged, so was possible changes in indices for metabolism-related hormones.80ICR (Imprinting Control Region) mice,40males and40females, were included in the study. The male and female group was divided into8groups, respectively, which included control group, high hyperlipidemia model group, fructose group, maltitol group, xylitol group, resistant dextrin group, ordinary dextrin group and starch group, with5mice in each group.The study lasted17days, during which the tested agents were administered intragastrically to each mice on a daily basis.0.5%solvent was given to the controls, and the dosage was0.1g/10G for mice of all groups.After16days in succession of intragastric administration, mice in all groups, except for the controls, were intraperitoneally injected with75%egg yolk in a dose of0.5ml/mouse (the purpose of which was to established mouse models with acute hyperlipidemia syndrome, to be used in testing of various acute hyperlipidemia detection products, as well as in protecting hepatic functions. And then, after a12hour water fasting and2hours before removing mice eyes to get blood samples, all mice were administered intragastrically. The mice were sacrificed before collecting blood samples. Liver tissue was taken to be used later in determination of related blood and hepatic biochemical indices.It’s shown in the results that preventive effect upon acute hyperlipidemia and hyperglycemia was observed in mice from maltitol group, xylitol group and resistant dextrin group. Levels of hepatic triglycerides, hepatic total cholesterols, serum triglycerides and blood glucose in female mice from maltitol group, xylitol group and resistant dextrin group were lower compared with their corresponding controls. A very good improvement on serum triglycerides and high density lipoprotein levels was found in male mice from maltitol group, xylitol group, and resistant dextrin group as well.Overall, sugar alcohols and resistant dextrins, as digestion-resistant carbohydrate, due to their special mode of digestion and their resistance to digestive enzymes in small intestine, lowered elevated blood glucose and blood lipid levels in mice, and in the meantime, improved the compensatory effect on acute hyperlipidemia..