Investigation On The Use Of Antibacterial Drugs In The Elderly Hospitalized Patients In A Hospital

Objective To investigate antimicrobial usage and effects of drugs in patients in thishospital, further investigate the use of antibacterial effect of clinical application of drugon elderly patients and other factors of antibacterial drugs in elderly patients, in order toimprove the provision of scientific and effective basis for reasonable use in hospitalizedelderly patients of antibacterial drugs.Methods According to the hospitalized elderly patients in clinical departments, bymulti-stage random cluster sampling method, selected from different departmentsrelated to the filing integrity records. The extraction of hospitalized elderly patients withstatistical analysis of276cases. Analysis of antimicrobial drug use situation and itsinfluence factors.Results The extraction of8clinical departments in20111~June276hospitalizedelderly patients medical records. Among them146were male,52.9%, female130cases,accounting for47.1%; the oldest was92years old, the youngest60years old, theaverage age is71.50years old; in the clinical departments in the extraction, elderlypatient records distribution:1of15cases,2of21cases,26cases,3familiesDepartment of orthopedics,16cases of Urology in35cases,2of48cases,64cases in3families,1subjects,57cases, accounted for6%,8%,10%,4%,13%,18%,24%,21%,46cases accounted for16.7%of total surgery, Department of internal medicine,179cases accounted for64.9%; in276medical records,193patients used antibiotics,accounting for69.90%, the use of antibacterial drugs3265times, one of the drug in77cases accounted for27.9%, two drug97cases accounted for35.1%, more than tripleand19cases accounted for6.19%; the use of antibacterial drugs:71cases with indications of preventive antibiotics accounted for25.7%,89cases treated withantibiotics32.2%, no indication of application20cases accounted for7.2%, preventionand treatment of13cases accounted for4.7%of antibacterial drugs. Etiology:antimicrobial records of all193cases only4copies made etiological examinationaccounted for only1.4%. The route of administration statistics,250cases of simplestatic administration accounted for90.6%,26cases of mixed drug accounted for13.1%.Age, length of stay, medication days and hospital costs related analysis showed, thenumber of days of hospitalization and drug days and hospital costs were positivelycorrelated (rs=0.287), medication days (rs=0.902).Separately for different gender, occupation, departments, admission diagnosisdiagnosed diseases, and other factors initial selected combination for statistical analysis,results suggest that the differences were significant differences (P<0.05); same time ondifferent factors such as inter-gender drug indications for statistical analysis, the resultsshowed that only occupation is not shown statistically significant differences in otherfactors were statistically significant (P all <0.05)Drug utilization index of drug use were analyzed, a percentage of the top10antibacterial drugs, DUI <1, indicating lack of the daily dose, the use of unreasonable.According to the use frequency of use of antimicrobial drugs were analyzed andevaluated for the B/A value of [B/A=a pharmaceutical sales amount (B)/the drugDDDS (A)], Ranking among the top ten of cefoperazone sulbactam is B/A=1, goodsynchronization, consistent with the price of drugs and patient acceptance; head ofcefuroxime Enoxacin B/A larger, suitable price, and is easily accepted by patients; otherB/A <1, prices are high, such as amoxicillin clavulanic potassium ketone, aztreonam,low degree of patients accepted.Combined application of antibiotics that have a synergistic effect, also have antagonisticeffects. For applications with a clear indication, combined treatment can reduce the sideeffects, increasing its synergistic effect. To improve the detection of bacteria detection rate, so that the drug targeted use ofantibiotics, reduce blindness, reduce the medical cost of patients, improve the rationaluse of drugs.According to the elderly patients with physiological characteristics and individualdifferences in drug development, drug concentration, individual treatment.The old man’s psychological counseling, to strengthen health education, to improvemedication compliance.Conclusion The hospitalized days longer hospitalized elderly, hospitalization expensesalso higher; bacterial examination rate is the main factor affecting the rational use ofdrugs, detection rate is lower in elderly patients with antibiotics is the fundamentalreason for the irrational use of drugs and drug use, frequent change of randomness, thatis not up to the disease cure or alleviate the purpose, and increase the resistance ofbacteria; no means the combination syndrome, is not only a waste of medical resources,also increase the risk of adverse drug reaction.