Clinical Observation Of Yixintai In Treating Chronic Heart Failure Patients Of Qi Deficiency, Blood Stasis And Water Stagnation Syndrome

Objective:To observe and discuss the clinical effect of Yi Xin Tai for the treatment of chronic heart failure patients with syndrome of Qi deficiency and blood stasis of water stop, and to investigate the influence on NT-proBNP.Methods:60patients who met the inclusion criteria were randomly divided into treatment group and contrast group with30cases in each. The contrast group was treated with conventional western medicine treatment and the treatment group was treated with conventional western medicine treatment and Yixin thai. The course of treatment was1month. The changes of clinical symptom score, signs of patients, tongues, pulse,6minutes’walk test, the index of heart color doppler ultrasound (SVEDD. SVESD, EF, E/A), the changes of plasma NT-proBNP and other indicators were observed before and after the treatments of two groups of patients.Results: 1. the treatment group and the contrast group could significantly improve patients’symptoms, signs of bodies,6minutes’ walking distance, symptoms of primary disease (CH F) arrhythmia and ECG, the difference was statistically significant (P<0.05), and the treatment group was better than the contrast group, the difference was statistically significant (p<0.05).2. compare the echocardiogram indexes before and after the treatments:①there was no significant difference in the two groups before treatments (p>0.05),②According to the paired t test, there was a trend of improvement of LVEDD, LVESD, E/A compared with the treatments before, but without statistical significant difference (p>0.05), according to the group t inspection, the treatment group and the contrast group had no statistical significant difference, either (p>0.05), which meant that there were no difference of LVEDD, LVESD, E/A before and after the treatments, and for treatment group and contrast group there were no difference, neither;③According to the t test, the difference of EF value had statistical significance (p<0.05) compared with the treatment before, and the improvement of treatment group was better than the contrast group (p<0.05).3. The plasma NT-proBNP levels of the treatment group and the contrast group were decreased1135.00±725.30pg/ml and929.86±738.40pg/ml, than that of the treatments before. From the paired t test, the two groups had statistical significance (p<0.05)before and after the treatments, and the decreasing level of the treatment group was higher than that in the contrast group, which meant that the treatment group was better than the contrast group in reducing plasma NT-proBNP(p<0.01).Conclusions:1. Yi Xin Tai can obviously improve the clinical symptoms in patients with heart failure and improve the patients’ state of hypoxia under heart failure.2. From the the index of heart color doppler ultrasound and NT-proBNP level, it significantly more objectively indicated that it can improve cardiac function.3. In the treatment process, it was safe and effective and without obvious adverse reactions, it is worthy of popularization and application.