Relavent Research Between Serum Oxidized Low Density Lipoprotein And Carotid Atherosclerosis

Cardiovascular disease caused by arteriosclerosis continue to increase, ithas been a serious threat to human health. In addition to natural aging, age andother factors, such as hyperlipidemia, hypertension, diabetes, smoking, geneticdiseases. The study found that there are many risk factors can induce andpromote the development of atherosclerosis. Atherosclerosis has become asystemic disease now.It has been confirmed the increase of oxidized low-density lipoprotein(ox-LDL) plays a key role rather than Low density lipoprotein (LDL) in theinitial stages of atherosclerosis. And also ox-LDL plays important promotingrole in the formation process of atherosclerosis plaques, vascular stenosis, andeven plaque off and thrombosis[1-4]. Humans should recognize the role of theox-LDL in the AS, in order to take effective treatment measures to prevent ordelay the development and progression of atherosclerosis, and also hassignificant meanings in protection of vascular health.In this study, the whole carotid intima cases of all subjects were detected bycolor Doppler ultrasound, and measured the ox-LDL levels in the serums whichwere drawed from the patients with atherosclerosis (ie, experimental groups)and the same period patient healthy (control group) by ELISA, and then toanalyze the correlation between different levels of ox-LDL and carotid atherosclerosis, and to investigate the clinical significance of the serum ox-LDLlevels in carotid atherosclerosis.The patients are collected in the China-Japan Union Hospital of JilinUniversity during January2013-December2013, the inpatient neurologyatherosclerosis patients (experimental group) are240cases, compared withhealthy patient (selected in accordance with the exclusion criteria control group)80cases. According to the degree of carotid intimal injury selected cases aredivided into three groups: the carotid artery intimal thickening group (1.0mm≤IMT <1.2mm)(A group):80cases,40cases of men and40cases of women,average age are56.60±5.37years old; carotid artery plaques group (IMT≥1.2mm, but diameter stenosis of blood vessels≤50%)(B group)80cases:40cases of soft plaque and mixed plaque (B1subgroup):20cases of men and20cases of women, average ages are55.50±5.28years old; hard plaque group(B2subgroup)40cases,20cases of men and20cases of women, average agesare54.90±5.78years old; carotid artery stenosis group (blood vessel diameterstenosis>50%, at the same time confirmed by the neck computed tomographicangiography (CTA).(C group)80cases:40cases of men and40cases ofwomen, average ages are56.60±5.86years old. All subjects in the experimentalgroup were divided again in accordance with the clinical symptoms:cerebrovascular disease groups and non-cerebral vascular disease group. Allselected groups are required to meet the following criteria, otherwise beexcluded, namely: within the last two months, no application of inflammation- suppressing drugs such as non-steroidal anti-inflammatory drugs, steroids,immunosuppressants, and opiates, as well as all influence serum levels ofoxidized low density lipoprotein drugs while excluding arterial dissection,radiotherapy neck stenosis, fibromuscular dysplasia, aneurysms, which cancause blood vessels to narrow. All are measured using an human serum ox-LDLlevels ELISA kit, and analysis of serum ox-LDL levels and the degree ofcorrelation between carotid atherosclerosis, the results were analyzedstatistically.The results showed that:①serum ox-LDL levels of group A, B and C were higher compared withthe control group, and serum ox-LDL levels showed gradual increasing duringgroup A, B, C group, the difference was statistically significant (p<0.05).②serum ox-LDL of group B1in patients was higher than values of groupB2, the differences was statistically significant (p <0.05).③serum ox-LDL values of clinical cerebrovascular disease group was nothigher than that of non-clinical group, the difference was not statisticallysignificant (p>0.05).Conclusions:In summary, we can conclude that serum ox-LDL levels can be used as animportant factor for the severity of atherosclerosis; Meanwhile ox-LDL levels inserum can be used as an important reference for the evaluation of plaquestability. Therefore, it has a significant meaning to inhibit atherosclerosis process that has a clear recognize to the mechanism about ox-LDL serum levelsin atherosclerotic, and to take effective measures as soon as possible.