Association Between The Serum BDNF And HMGB1Levels In Type2Diabetic Peripheral Neuropathy Patients

Objective:To investigate the association between serum Brain-derived neurotrophic factor (BDNF) and High-mobility group box-1(HMGB1) levels in type2diabetic peripheral neuropathy patients.Methods:Sixty patients with type2diabetes mellitus were recruited from Lanzhou University Second Hospital including30T2DM and30type2diabetic peripheral neuropathy patients. Thirty healthy control subjects were selected. Diabetes duration, age,lipids,blood pressure,fasting and two-hour postprandial plasma glucose, glycosylated haemoglobin A1c were collected. The serum levels of BDNF and HMGB1were quantified using ELISA, BDNF and HMGB1mRNA was detected by quantitative real-time RT-PCR in peripheral blood mononuclear cells (PBMC).Pearson correlation method tested the association between serum BDNF and HMGB1levels in type2diabetic peripheral neuropathy patients.Results:The level of BDNF was significantly lower in the T2DM group compared to control subjects (P<0.05), whereas the level of HMGB1was higher. The level of BDNF was lower in the DPN group than in the T2DM group. In type2diabetic peripheral neuropathy patients., BDNF was showed a significant relationship between BDNF and HMGB1(r=-0.425,P<0.05).Conclusion:In type2diabetic peripheral neuropathy patients there was significant correlation between the levels of HMGB1and BDNF. Both BDNF and HMGB1may participate in the process of type2diabetic peripheral neuropathy.