Clinical Observation Of Aerosol Inhalation Of Ambroxol In The Effects Of Sputum Elimination

Background:Off-label drug use equals to unlabeled uses. It is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, unapproved dosage, or unapproved forms of administration. Despite aerosol preparations and inhaling routes of ambroxol have been introduced and used in many studies, there is no inhalation route has been mentioned on the current instruction used in clinic of mucosolvin injection (the revised edition of2008). So inhaling mucosolvin is still off-label use. Evidences based on medicine also need to be found.Objective:This paper uses normal saline,3%sodium chloride and ambroxol aerosol inhalation, the three clinical commonly used methods of inducing sputum. In this way, we can observe the efficacy of sputum inducted by conventional inhalation of mucosolvin.Sources and Methods:1. Object of study:30cases of patients with AECOPD, who cough productively and can accept the inhalation of medicine, were selected in Shandong provincial hospital affiliated Shandong University from2013.11to2014.01and divided randomly into3experimental groups.2. Spray inhalation:The mixture of drugs drove by flux oxygen were given to patients as follow. The patients in group A:normal saline (NS)8ml inhalation two times a day (bid), group B:NS6ml+10%NaCl2ml bid inhalation, group C: NS4ml+4ml bid inhalation of ambroxol. Each time is about15min.3. Searching of sputum:To collect the sputum of patients before and after inhalation. The collecting time is from7a.m. to7a.m. of second day.4. Indexes of observation:We collected respectively the selected patients’sputum of do, d1, d2, d3. We compared the volume, dry/wet weight and length of string of the three groups’ patients’ sputum, those showed the differences among different induced methods. Comparisons of sputum volume on do and d3stated the efficacy of the induction.5. Statistical analysis:The data collected was saved daily in the form of Excel. All data analysis was performed using SPSS20.0software. The differences among the three unbalance data were performed by non parametric independent sample procedure. P values less than0.05were considered statistically significant.Results:1. Sputum volume:the sputum volume of group C was more than that of group A and group B (P<0.05, significantly different, with statistical significance.).2. Stringing length:the sputum drawing length of group C lower than that of group A and group B (P<0.05).3. Dry/wet weight:the ratio of group C lower than that of group A and group B (P <0.05).4. Adverse reactions:the patients of group B felt salty in mouth. There were no other adverse reactions in the other two groups.Conclusions:1. The three nebulizations were proved to be beneficial to the sputum secretion of the patients.2. The effect of mucosolvin aerosol inhalation was better than NS and concentrated sodium inhalation.