| 1. Background:rheumatic diseases, refers to disease appears pain occurs, weight forward, adverse events and other symptoms of limb bones, joints, muscles, brings the patients great pain. Rheumatic diseases of modern medicine can be as articular synovitis. Modern research on articular aynovitis mostly concentrated in the pathogenesis,diagnosis and treatment,data mining of the drug laws is not enough. As people continues to deepen understanding of these diseases, especially in the process of China’s aging population continues to accelerate, rheumatic disease has also been paid extensive attention of scholars. To some extent, Chinese medicine has its own advantage in the prenvention of rheumatic diseases.Traditional Chinese medicine have no nankylosing spondylitis, rheumatoid arthritis and osteoarthritis disease, but there are similar in many medical records and the clinical manifestations, their associated disease of traditional Chinese medicine of rolls for "da lv","wang bi" and "gu bi", the main syndrome performance as lumbar, sacral spine or hands feet small joints, wrist, elbow and knee joint pain, stiffness, and adverse events. Through these areas for many meridians line domain, so the three kind of rheumatism and the pathogenesis and clinical manifestations of all these courses in the meridians are closely related.Professor Yan Xiaoping is the fourth batch of national famous old Chinese medicine experts, academic experience of professor JiaoShuDe heir, rheumatism, deputy director of professional committee member of China association of Chinese medicine, the Chinese society of combining traditional Chinese and western medicine rheumatism, deputy director of professional committee members. She engaged in traditional Chinese medicine, combined Chinese and western medicine in the treatment of rheumatism and the scientific research work, especially for the diagnosis of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis treatment, has accumulated rich experience in clinical practice.In the process of clinical diagnosis and treatment of rheumatic diseases, professor Yan Xiaoping original "five serial" therapy, through multi-level and multiple targets for treatment, produce synergistic effect, as has lifted a large number of patients with pain."In traditional Chinese medicine is given priority to" treat rheumatism, professor yan often tired syndrome differentiation theory guiding syndromes and herbs, clinical outcome, more and more been recognized by the broad masses of medical fellow.2. Objective:Objective of this study was to use the auxiliary platform for data mining heritage of traditional Chinese medicine, professor summarizes Yan Xiaoping uses the experience of treatment of rheumatism tired syndrome differentiation theory, to better inherit and carry forward the name old doctor of traditional Chinese medicine experience, clinical, in order to better service for patients with pain.3.method3.1Collect consilia of professor Yan Xiaoping from July2013to February2014, which record the treatment of ankylosing spondylitis, rheumatoid arthritis, osteoarthritis. The total of500basis, including each200basis ankylosing spondylitis, rheumatoid arthritis, osteoarthritis basis100. Will collect basis after standardization, drugs, symptoms in database is established.3.2Build a database for standardization first, then input to the inheritance of traditional Chinese medicine auxiliary platform, frequency analysis, correlation analysis, rule analysis, complex system entropy clustering, such as statistical analysis, the research contents include symptoms statistics, four gas mixed drugs frequency statistics, and belongs to the statistical rule analysis, new medicine analysis, and etc.3.3Using traditional Chinese medicine theory to analyze the above statistics results, summarizes the application tired every kind of rheumatism of diagnosis and treatment of syndrome differentiation theory. Analysis of the above three kinds of rheumatism, the similarities and differences in the same local symptoms when using drugs, find out each kind of rheumatism unique regularity in the tired day.4. Result4.1Through frequency analysis found that most patients with ankylosing spondylitis is lumbar di ministry pain, back pain and chills, the symptom such as morning stiffness, the drugs used in radix dipsaci, dog ridge, see more such as mulberry parasitism; Most of the symptoms in patients with rheumatoid arthritis is between both hands and joint swelling pain, wrist joint swelling pain, pain in the shoulder joint, knee joint swelling pain, chills, the drugs used to scurfpea fruit, rhizoma drynariae, rhizoma anemarrhenae, windproof, orientvine see; Osteoarthritis is the most symptoms in patients with knee joint swelling pain, chills, lower-back pain, hip pain, etc., used drugs to wind, zedoary, live alone, cassia twig, mulberry parasitism, malaytea scurfpea fruit, etc. The drug are main to liver and kidney, spleen, bladder, multiple cosin and temperature.4.2Through the analysis of the association, rules, and find out the yan teacher treat rheumatism drug use and the corresponding relation of onset of symptoms. Ankylosing spondylitis, for example, when there is a pain, lumbar di ministry often use strong kidney du fang, eucommia bark, radix dipsaci, mulberry parasitism, rhizoma drynariae, malaytea scurfpea fruit, drugs such as live alone; Back pain, common kidney strong overseers, dog ridge, notopterygium, windproof, eucommia bark, radix dipsaci, mulberry parasitism; In the hip joint pain, often use milkvetch seed, turmeric, turmeric; Knee pain often used orientvine, pepper stem, Chinese starjasmine, caulis spatholobi, radix achyranthis bidentatae; Neck pain is used when puerarin, common clubmoss herb; Groin pain often use fruit, sweet attached, sichuan Tong white thistle; Deep hip pain, often using radix bupleuri, main yuan hu, Tong white thistle; Red eye pain, commonly used mulberry leaf, chrysanthemum, radix scutellariae, white mulberry root-bark, bone, skin, Tong white thistle; Flanks chest pain often use green tangerine peel, Sue, almond, turmeric, drugs such as attached.4.3Office of all drugs on clustering analysis of five new method combination. Prescriptions which predominantly exorcism has dehumidification, heat cold cold blood, the efficacy of clear, hot and humid, predominantly tonic prescriptions multi-purpose tonic liver and kidney, the effect of replenishing qi and blood.5. Conclusion:5.1Professor Yan Xiaoping in the treatment of rheumatism, need to see where the pain, frozen in what place, its belong to what, what is, and even to the zang-fu organs, according to the clinical symptoms of local meridian attribution, at the same time pay attention to the use of "led by the medicine", will be tired syndrome differentiation theory throughout the course of the diagnosis and treatment of clinical outcome.5.2Professor Yan Xiaoping think most common rheumatism have kidney deficiency, deficiency and bones and muscles alongwith the internal cause of sun be the spirit, the cold green abuse within the origin. Liver and kidney deficiency is the basis of many rheumatism, treatment when time does not forget kidney, strong bones and muscles.5.3Professor Yan Xiaoping according to the theory of tired syndrome diagnosis and treatment of various kinds of rheumatism, although the drugs used approach is similar, but experience carefully, still slightly in different place. For the treatment of ankylosing spondylitis drugs, the most benefit of power, pay attention to thrift school. And the treatment of rheumatoid arthritis drug benefit power to diminish, but eliminate pathogenic t2dm with drugs. The prescription in the treatment of joint, to further increase the line with qi, activating blood, t2dm, analgesic efficacy of drugs, tonic than before both liver and kidney of force. |
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