| Background:Knee Osteoarthritis (KOA) is a chronic joint disease caused by the degeneration of articular cartilage. The main pathological features of KOA are articular cartilage damage and osteophyte formation. It is a common disease with High incidence, because Knee Osteoarthritis is a slow process of pathological changes, is a joint degeneration and aging. The major clinical manifestations are knee pain, stiffness, swelling and limited movement, etc.; severe joint instability and deformity, severe loss of joint function eventually. According to current clinical practice, Chinese and Western health care treatment has no obvious effect towards patients with severe knee osteoarthritis. It is resolved only by surgery. Therefore, for patients with early knee osteoarthritis, treatment and prevention are particularly important. The treatment of early knee osteoarthritis in both Traditional Chinese and Western Medicine is generally conservative therapy. However, the side effects of Western Medicine treatment are larger, especially for the influence of the liver and kidney, so Western Medicine should not be long-term use, relatively limited. Traditional Chinese Medicine holds that knee osteoarthritis is mainly caused by wind-cold-dampness evil invasion and blockage of joints. Traditional Chinese Medicine treatment of early knee osteoarthritis has its own characteristics and advantages that through diagnosis and treatment with internal and external, it can relieve symptoms and improve governance to achieve the effect of functionality. External treatment of Traditional Chinese Medicine is a common method. It is easily obtained, economical and practical, and has small toxicity. Moreover, it has been widely used in clinical practice and recognized by a great number of patients.Objective:It objectively observes and evaluates the clinical efficacy of chubi lotion’s treatment for early knee osteoarthritis in order to verify chubi lotion’s characteristics and advance in the treatment. Methods:60patients who met the criteria in patients with knee osteoarthritis from Wangjing Hospital outpatient clinic were divided into experimental group (30cases) and control group (30cases) through using randomized blocks. Experimental group:affected knee accepted chubi lotion Fumigation treatment,20minutes each time,2times a day for2weeks as a course of treatment; Control group:affected knee accepted Voltaren ointment treatment, smearing affected knee3times a day for2weeks as a course of treatment. According to the design of TCM syndrome score, VAS pain score and HSS knee score, to observe treatment effect and make a scientific evaluation.Results:The result data statistics:the experimental group’s TCM syndrome score (17.90±4.33), HSS score (59.87±13.69), VAS score (6.69±1.38) before treatment; experimental group’s TCM symptoms score (8.27±2.23), HSS score (84.89±6.58), VAS pain score (1.99±1.08) after treatment. Comparing with the experimental group’s TCM symptom score, HSS score and VAS scores before treatment, they had a significant difference after treatment, P <0.01. Before treatment the control group’s TCM symptoms score (1.99±1.08), HSS score (1.99±1.08), VAS score (1.99±1.08); after treatment the control group’s TCM symptoms score (10.72±2.92), HSS score (75.48±6.23), VAS pain score (2.59±1.10). Comparing with the control group’s TCM symptom score, HSS score and VAS scores before treatment, they had a significant difference after treatment, P<0.01. Both groups’TCM syndrome score, HSS score, VAS score had significant differences after treatment, P<0.05.TCM symptoms efficacy analysis results: experimental group: clinically cured in3cases (10%), markedly improved in15cases (50%), effective in11cases (36.67%), ineffective in1case (3.33%), markedly effective rate of60%, the total effective rate of96.67%. Control group: clinically cured in0cases (0%), markedly improved in9cases (30%), effective in17cases (56.67%), ineffective in4case (13.33%), markedly effective rate of30%, the total effective rate of86.67%. Comparing the efficacy of two groups after treatment, there were significant differences, P<0.05. It illustrated that experimental group’s efficiency was higher than control group’s and was statistically significant.After treatment, experimental group and control group’s TCM symptom score, HSS knee score and VAS pain score were significantly different comparing with those before treatment. It demonstrated that two groups has exactly efficacy in treatment of the early knee osteoarthritis. There was a significant difference in clinical efficacy between two groups after treatment. Experimental group is superior to control group.Conclusion:Through the studies, the results showed that:1. Chubi lotion can effectively improve clinical symptoms in treatment of the early knee osteoarthritis with high safety, small side effects, etc.2. Chubi lotion has significant efficacy in treatment of the early knee osteoarthritis and is superior to Voltaren ointment.In conclusion, it achieved the purpose of this topic through clinical research, cleared the clinical efficacy of chubi lotion in treatment of the early knee osteoarthritis and provided reference value and infrastructure basis for clinical application. |
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