Primary Application Of Automated Breast Volume Scanner For The Diagnosis Of Breast Lesions

Objective: To evaluate the value of Automated Breast Volume Scanner (ABVS) inthe diagnosis of breast lesions, and to compare with the Handheld Ultrasound (HHUS)examinations.Methods: The study prospectively evaluated130lesions in128women who werescheduled for open biopsy. The patients underwent ABVS and HHUS. Theaccuracy, sensitivity（Sen）, specificity（Spe）, positive predictive value (PPV),negative predictive value (NPV), positive likelihood ratio (+LR), and negativelikelihood ratio (-LR) for ABVS and HHUS images were calculated usinghistopathological examination as the gold standard. The area under the receiveroperating characteristic (ROC) curve is used to estimate the accuracy of the twomethods. The maximum diameters of the lesions were measured on ABVS and HHUSwere compared with the pathological results. We used kappa statistics to interpretagreement between the two methods and diagnostic relevant factors (such as lesionshape, orientation, margin, echo pattern).Results: The accuracy, sensitivity（Sen）, specificity（Spe）, positive predictive value(PPV), negative predictive value (NPV), positive likelihood ratio (+LR), andnegative likelihood ratio (-LR) of ABVS were95.4%,94.6%,96.4%,97.2%,93.1%,26.28,0.06, respectively, which of HHUS were89.2%,90.5%,87.5%,90.5%,87.5%,7.24,0.11,respectively; and there was significant difference between ABVS andHHUS (χ2=68.532,P=0.00);The measurements by ABVS and HHUS were bothpositively correlated with those on pathological examination(r=0.757and0.679，bothP＜0.01)， The coefficient of correlation between histopathologic and ABVSmeasurements was higher than that between histopathologic and HHUSmeasurements.Substantial agreement was obtained for lesion shape, orientation,margin, lesion boundary，echo pattern, posterior acoustic features, calcification andBI-RADS(K=0.79,0.74,0.76,0.69,0.68,0.71and0.70, respectively).Conclusion: ABVS can provide more diagnostic information to breast lesions, then improve the accuracy of diagnosis of breast lesions, It also can be more clearly showsthe range of lesions, provide more effective reference value to assess the size ofmalignant breast lesions.