The Expression And Significance Of P120-catenin And VE-cadherin In Intracranial Aneurysm Walls

Objective：The etiology and pathogenesis of intracranial aneurysms is complex, related tomany factors in vivo and in vitro.We detected P120-catenin and VE-cadherin inintracranial aneurysm walls to explore preliminarily P120-catenin and VE-cadherininvolve in the possible mechanism of intracranial aneurysms occurrence and rupture.Methods：We collected aneurysm specimens of25cases in Neurosurgery Department ofthe first affiliated hospital of Nanchang university from February2013to January2014, including5cases of unruptured aneurysms and20cases of rupturedaneurysms, in addition we collected4cases of superficial temporal arterys as acontrol. Immunohistochemical method was used to detect the expression ofP120-catenin and VE-cadherin in normal cerebral artery walls, unruptured andruptured intracranial aneurysm walls.Results：Immunostaining intensity scores of P120-catenin and VE-cadherin in thesuperficial temporal artery were higher than that of intracranial aneurysms,however,immunostaining intensity scores of P120-catenin and VE-cadherin in unrupturedintracranial aneurysms were higher than that of ruptured intracranial aneurysms. Ttest between any two groups was statistically significant difference (P <0.05). Thecorrelation analysis of P120-catenin and VE-cadherin showed r=0.97.Immunostaining of P120-catenin and VE-cadherin in superficial temporal arterys isvery clear tan line-like arrangement, they are continuously even distributed in thevascular endothelium which has complete cortical structures,no local faults andmissing. Immunostaining of unruptured intracranial aneurysms shows that P120-catenin and VE-cadherin is small part of the color lighter or no color, intermittentlyuneven arrangement and has localized aneurysm walls fracture. P120-catenin andVE-cadherin in ruptured intracranial aneurysms only has trace immunostaining and is scatteredly distributed in aneurysm walls, no color in most aneurysm walls;Celllayer structure of aneurysm walls is not complete, most areas appear broken andmissing.Conclusions：The expression of P120-catenin and VE-cadherin in superficial temporal arterysis higher than that of intracranial aneurysms, and the expression of unrupturedintracranial aneurysms is higher than that of ruptured intracranial aneurysms.Thisstudy provides a theoretical basis for our understanding intracranial aneurysms at themolecular level which indicates that with the loss and deletion of P120-catenin andVE-cadherin of vascular endothelials contribute to occurrence and rupture ofintracranial aneurysms；The expression of P120-catenin and VE-cadherin in normalarterial endothelial cell layer and intracranial aneurysms shows a high positivecorrelation.