The Clinical Studies On Influence Factors Of Left Ventricular Function In Patients With Acute Myocardial Infarction

ObjectiveTo study the influence factors of left ventricular function in patients withacute myocardial infarction.Methods160patients with acute myocardial infarction(AMI) who have undergoneemergency or elective percutaneous coronary intervention(PCI) in the FujianProvincial Hospital Cardiology from January1,2012to December31,2012wereenrolled. The patients were divided into three groups according to the time of PCI.Group A:underwent emergency PCI within12hours; Group B:underwent electivePCI in the pathogenesis of12hours to seven days; Group C:underwent electivePCI inthe pathogenesis of eight to fourteen days. In the study, echocardiography was used tomeasure the left ventricle ejection fraction(LVEF) of AMI patientsmyocardialinfarcted for7-14days. Meanwhile, influence factors of age, sex, hypertension,diabetes, smoking, glucose, lipids, troponin I values, NT-pro BNP values and PCI ofpatients were recorded, and the correlation between these factors and LVEF wereassessed.Results1. The time of PCI was negatively correlated with LVEF of AMI patients(t=-2.354，P=0.02). The LVEF of Group A was significant higher than that ofGroup C, there wasstatistical significant(P<0.05). The difference in LVEF betweenGroup Aand GroupBand LVEF betweenGroup Band Group C were no statistically significant(P>0.05).Meanwhile, the study shows that the most common case of AMI vascular involvementwasthe simultaneous three-vessel involvement. The LVEF of single-vesselinvolvement was significant higher than the multi-vessel involvement, there werestatistical significant(P<0.05). 2. After adjustment, results of the multiple regression analysis showed that troponinI(t=-3.409，P=0.001), N-terminal-pro-brain natriuretic peptide(t=-5.484，P=0.000)and fasting blood glucose(t=-2.872，P=0.043), Coronary artery involvement（t=-3.390，P=0.001）were negatively correlated with LVEF of AMI patients. There wereno significant correlation between the LVEF of AMI and the hypertension, glycatedhemoglobin,2-hour postprandial glucose, smoking, total cholesterol, triglycerides,low－density lipoprotein cholesteroland high-density lipoprotein cholesterol.Conclusions1. Patients with AMI underwent emergency PCI within12hours had higher LVEFthan that underwent emergency PCI after8days. The most common vascularinvolvement of AMI was the simultaneous three-vessel involvement. The LVEF ofsingle-vessel involvement was significant higher than the multi-vessel involvement.2. The troponin I, the N-terminal-pro-brain natriuretic peptide, the time of PCI andthe fasting blood glucose were negatively correlated with the LVEF. They were theindependent predictor and sensitive indicator of left ventricular functionaftermyocardial infarction.