Protective Effects Of Fentanyl Combined With Propofol On Pulmonary Ischemia Reperfusion Injury In Rats

Objective To study the expression of nuclear factor-κB(NF-κB) in the lung and plasma separately and explore the possible mechanisms of fentanyl combine with propofol on lung ischemia-reperfusion injury of rats.Method The40Wistar male rats weighing220～270g were divided randomly into five groups which were pretreated differently. The values of NF-κB in rats’ lung was detected by using immunohistochemical method, the lung tissue observed in vitro and under the microscope after HE staining, the rats’ arterial oxygen pressure and the lung tissue W/D ratio were measured in each group.Results Compared with the I/R group, the F group, the P group, and the F+P group all followed the same trend:the NF-κB expression levels were obviously lower (P<0.01), the values of PaO2were obviously higher (P<0.01), and the W/D ratios were lower (P<0.01).Conclusions Fentanyl combined with propofol can significantly reduce lung ischemia-reperfusion injury, it may be that fentanyl combined with propofol can reduce the level of NF-κB in rats’ lung.