The Retrospective Study Of The Patients With Chronic Hepatitis B Liver Fibrosis With The Treatment Of Replenishing Qi To Invigorate The Spleen And Softening Hard Lumps

Objective To probe the effects of the patients with chronic Hepatitis B liverfibrosis with the treatment of replenishing qi to invigorate the spleen and softeninghard lumps, verify that using replenishing qi to invigorate the spleen and softeninghard lumps early to treat the patients with chronic Hepatitis B liver fibrosis canimprove patient’s clinical symptoms and indexes through the retrospective study ofthe indexes in the medical history of the80patients with hepatic fibrosis caused bychronic hepatitis B, provide new methods to treat the patients with chronic Hepatitis Bliver fibrosis with traditional Chinese medicine early application.Methods Using the method of parallel control study to make retrospectivestudy, looked up the80medical histories that they conform to Inclusion criteria inAffiliated Hospital of Henan Institute of Traditional Chinese Medicine for from2008to2013, divide40cases into GuZhangpian group and40cases into conventionalmedical treatment group according to nclusion criteria, recorded the changes ofcardinal symptoms(according abdominal distension, debilitation and poorappetite),secondary symptoms and signs(according hypochondriac pain, nausea,defecate, tongue nature, tongue nature and total score of symptoms), laboratoryindexes: hepatic fibrosis markers(HA, LN, PC Ⅲ, C Ⅳ), imaging indicators(the livercapsular, the diameter of portal vein, the diameter of splenic vein, the thickness of thespleen, echo and the right hepatic lobe largest diameter) and liver functionindexes(ALT, AST, ALB, TBIL) before they took Guzhangpian and after they tookGuzhangpian for one year, three years and five years respectively. Using Epidata3.1to set up the database, inspection level: α=0.05(P<0.05is deemed to statisticalsignificance, on the contrary that is no statistical significance). Using rank sum test toanalyse the changes of indexing of imaging indicators of the treatment group and the control group at different times, using independent sample T test to analyse thechanges of laboratory indexes at different times. Parameter estimation:95%CI.Results①imaging indicators. The indexing of imaging indicators has notobvious differentiation before they took Guzhangpian and after they tookGuzhangpian for one years, comparing the two groups has no statistical significance(P>0.05); the indexing of imaging indicators has obvious differentiation after theytook Guzhangpian for three years and five years, comparing the two groups hasstatistical significance (P<0.05).②hepatic fibrosis markers.After they tookGuzhangpian for three years and five years, HA in the treatment group has notobvious differentiation, HA in the control group has obvious uptrend, comparing thetwo groups has statistical significance (P<0.05); after they took Guzhangpian for threeyears and five years, LN in the treatment group has obvious downtrend, LN in thecontrol group has obvious uptrend, comparing the two groups has statisticalsignificance (P<0.05); after they took Guzhangpian for one year, three years and fiveyears, PC Ⅲ in the treatment group has smoothly downtrend, PC Ⅲin the controlgroup has obvious uptrend, comparing the two groups has statistical significance(P<0.05); after they took Guzhangpian for three years and five years, C Ⅳin thetreatment group has smoothly downtrend, C Ⅳin the control group has obviousuptrend, comparing the two groups has statistical significance (P<0.05).③liverfunction indexes. After they took Guzhangpian for three years and five years, ALT inthe treatment group has smoothly downtrend, ALT in the control group has obviousuptrend, comparing the two groups has statistical significance (P<0.05); after theytook Guzhangpian for three years and five years, AST in the treatment group hassmoothly downtrend, AST in the control group has obvious uptrend, comparing thetwo groups has statistical significance (P<0.05); before they took Guzhangpian andafter they took Guzhangpian for one year, three years and five years, ALB in thetreatment group and the control group have not obvious uptrend or downtrend, bothare in normal range, comparing the two groups has no statistical significance (P>0.05);after they took Guzhangpian for five years, TBIL in the treatment group hasdowntrend, TBIL in the control group has obvious uptrend, comparing the two groupshas statistical significance (P<0.05).④TCM syndrome.After they took Guzhangpian for three years and five years, the marks of abdominal distension, the marks of lack ofpower, the marks of poor appetite and the total marks in the treatment group haveobvious downtrend, the treatment group’s have obvious uptrend, comparing the twogroups has statistical significance(P<0.05).Conclusions①The retrospective study overifies that using replenishing qi toinvigorate the spleen and softening hard lumps early to treat the patients with chronicHepatitis B liver fibrosis can improve patients’ clinical symptoms and indexesobviously.②This study will provide some new ideas that treating liver fibrosis withtraditional Chinese medicine for the patients with chronic Hepatitis B liver fibrosisearly, reduce the incidence of liver cirrhosis and liver fibrosis, provide a strongevidence for treating liver fibrosis with traditional Chinese medicine.