Metabolic Syndrome And Adiponectin Gene Polymorphism In Han Population Of Northern Guangxi Zhuang Autonomous Region

Objective: To investigate the prevalence and epidemiologicalcharacteristics of metabolic syndrome(MS) in Han population receiving physicalexamination of northern Guangxi Zhuang Autonomous Region, and research therelationship between single nucleotide polymorphisms(SNPs) of the adiponectingene-11377and MS. Methods: A cluster sampling method was conducted inHan population receiving physical examination in the medical examinationcenter of Affiliated Hospital of Guilin Medical College from June2012toDecember2012with a representative sample of5318adults. Questionnaire wasconducted. Height, boby mass, blood pressure, fasting blood glucose(FPG),triglyceride(TG), total cholesterol(TC), low density lipoproteincholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), alanineamino transferase(ALT), aspartate amino transferase(AST) and uric acid(UA)were determined. Livers were checked by the color doppler ultrasonic tester. Inthis survey, the prevalence of MS and its components and the attributing factorsof MS were analyzed by logistic regression model according to the diagnosticcriteria of Chinese Diabetes Society in2004(CDS2004).150individuals wererandomly selected from the MS population as the object of study(MS group). Atthe same time,150cases of healthy people were selected as control group. The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was applied to analyze the differences of adiponectin gene-11377C/G in the genotype and allele frequency between cases and controls.Many anthropometric and biological indices were compared between cases andcontrols in different genotype carriers. Results:(1) The prevalence of MS in thissample was12.8%, and15.2%in male,10.0%in female. Compared to femalepopulation, male participants showed a much higher prevalence (P＜0.01).(2)Among the components of MS, the prevalences of overweight and(or) obesity,hyperglycemia, hypertension and dyslipidemia were36.9%,12.7%,24.2%,32.4%. The prevalence of overweight and(or) obesity was highest.(3) Themultivariable stepwise analysis extracted sex, age, UA and fatty liver as majorrisk factors for MS.(4) There was no significant difference of the distribution ofthe genotype and allele frequencies between MS and control groups (P＞0.05).(5) The characteristics of body mass index(BMI), FPG, blood pressure, bloodlipid and UA were no significant among different genotypes in MS and controlgroups (P＞0.05). Conclusions:(1) The prevalence of MS in a sample may beincreased significantly. It becomes a public health problem required urgentattention for prevention and treatment to reduce the incidence of cardiovasculardisease.(2) The incidence of MS is not closely related with the adiponectin genepolymorphism at-11377C/G in Han population of northern Guangxi ZhuangAutonomous Region.