Hormone Replacement Therapy In Postmenopausal Women With Osteoporosis Clinical Research

Objective：This paper presents a method of investigating the short-term efficacy andsecurity of Hormone Replacement Therapy in the treatment of postmenopausal osteoporosis, aswell as hormone replacement therapy combined with calcium therapy is the best method forthe treatment of postmenopausal osteoporosis.Methods：This article selects100cases with postmenopausal women in our hospitaloutpatient service from June2012to April2013; the patients were randomly divided intoexperimental group and control group with25cases in each group. Experimental group wererandomly divided into three groups: A group were treated with hormone replacement therapycombined with calcium, group B were treated with hormone, replacement therapy; group Cwere given calcium treatment. A control group of25patients not given drug treatment.Before treatment, after treatment six months and one year detection of the four groups ofpatients with bone density, B-detected breast and endometrial thickness. A retrospectiveanalysis of the research targets, and statistically analyzed.Results：1.Hormone replacement therapy combined with calcium, Hormone replacementtherapy and calcium alone therapy of three treatments were postmenopausal women withosteoporosis bone density has improved to some extent, the difference was statisticallysignificant (P <0.05).2. hormone replacement therapy combined with calcium in the efficacyof the treatment of postmenopausal osteoporosis most significant.6months of treatment, thetotal efficiency of100%A group. Group B, the total efficiency of92%. Group C of the totalefficiency of64%.12%of the control group, the total efficiency. BMD increase the efficacy of the three groups was significantly better than the control group (P <0.01).3. Hormonereplacement therapy combined with calcium and hormone replacement therapy for women touse two methods of long-term treatment of postmenopausal osteoporosis, bone mineraldensity was significantly improved, the difference was statistically significant (P <0.01).1year of treatment, A group, the total efficiency of100%. Group B of the total efficiency of100%. Group C of the total efficiency of94%.4%of the control group, the total efficiency.4.Adverse reactions and safety evaluation: Hormone replacement therapy group (A and Bgroups) treatment have a certain influence on the endometrium. Endometrial cancer andbreast cancer were not found in both groups, treatment of an annual breast mass is not found,including four patients with mild hyperplasia of the breast (4%), no symptoms such as breasttenderness, no special treatment, do not affect drug treatment.Conclusion:1.Calcium combined hormone replacement therapy is the prevention andtreatment of postmenopausal osteoporosis in the short-term efficacy of the most significantways, is currently the best method of treatment.2Calcium combined hormone replacementtherapy, hormone replacement therapy and calcium therapy three treatments werepostmenopausal women with osteoporosis bone density have some degree of improvement.3Calcium combined hormone replacement therapy and hormone replacement therapy wassignificantly improved bone mineral density for long-term treatment of postmenopausalosteoporosis.4.Treatment of postmenopausal osteoporosis numerous different factors. For thelong-term interests of HRT in postmenopausal women outweigh the disadvantages, theirsafety and their crowd, medication, dose and regimen and life so closely.