| Objective To quantitatively evaluate the association between Ile105Val polymorphism of GSTP1 (glutathione S-transferase pi) and sensitivity to platinum-based chemotherapy in advanced gastric cancer.Methods The relevant published literatures about Ile105Val polymorphism of GSTPl and sensitivity to platinum-based chemotherapy in gastric cancer were retrieved from China National Knowledge Internet (CNKI), VIP, Chinese Biomedical Literature Data (CBM), Wan-Fang databases, PubMed, EMBASE and Cochrane Library. Clinical response (complete response and partial response) was employed to estimate chemosensitivity. Meta-analysis was conducted by the RevMan 5.2 software, odds ratio (OR) with 95% confidence interval (CI) were calculated. Publication bias was identified using Stata 12.0 software.Results A total of 6 case-control trials were recruited, which included 724 cases in advanced gastric cancer. The results of Meta-analysis showed the different statistical significance was found between GSTPl Ile105Val polymorphism and clinical response in the follow genotypes [GG+GA vs AA:OR=23%,95% CI (1.29～4.38), P=0.006; GG vs GA+AA:OR=3.66,95% CI (1.18～11.39), P=0.02; GG vs AA:OR=4.42,95% CI (1.28～15.26), P=0.02] and Asian population subgroups [GG+GA vs AA:OR=2.93,95% CI(1.33～6.48), P=0.008].Conclusion Polymorphism of GSTPlIle105Val(A/G) may be associated with platinum-based chemosensitivity in advanced gastric cancer. Because the small sample size and included trials only contained English and Chinese. Moreover, the sensitivity to chemotherapy and the drug resistance of the tumor is controlled by multiple genes together. We need more large sample, high-quality and combined detection of multiple genes studys to define it. |
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