| BackgroundMigraine is one of common diseases in Neurology Clinic. Characterized by parox-ysmal side or double-sided throbbing headache and nausea, and vomiting and photophobia, re-occurs after a period of rest. Headache could get relief in a quiet, dark environment or after sleep. A large number of people in our country have migraines that affect work, learning and life. As there is no effective way to prevent migraines, the risk of occurring dangerous complications could be increased. Patients with deficient-blood brain stroke have increased risk for the development of abnormal brain white matter, which can lead to declined cognitive function. Migraines can also be developed with a variety of disease such as epilepsy, depression and the emotional spirit obstacles. WHO proposed that migraines are similar to dementia, limbs paralyzation and serious spirit obstacles, which is one of chronic functional diseases that seriously affect work and life of patients。 The incidence of migraines is high in population and its detriment is great. Studies have shown that migraines and sleep disorders often coexist in one patient and incidence of sleep disorder in patients with migraine is higher than normal people . Currently there are a large number of studies have shown migraines is associated with sleep, however, there is currently very few studies on this subject. By searching Wanfang data library and PubMed, there are only more than 10 related articles for recent 15 years, which has a certain subjectivity as they used subjective questionnaire. The number of studies abroad in this area is also small and there are inconsistencies [251. Polysomnography (PSG) is currently an effective method to describe the sleep of subjects. In this study sleep of subjects were analyzed by Pittsburgh sleep quality index scale (PSQI) score. Subjects were monitored over night through polysomnography. Subjective and objective sleep of migarines patients is analyzed. The subjects of this research are common type of migraines in adult people:migraine with aura and migraine without aura. The criteria for selecting subjects are based on 2013 International Headache Society (IHS) classification and diagnostic criteria, whose ages are from 18 years old to 60 years old.ObjectiveTo compare sleep quality of migraine with aura and migraine without aura by using PSQI sleep scale and polysomnography (PSG) as well as to explore subjective and object sleep condition of migraine.MethodFrom December 2013 to May 2014 experiments were conducted in the Department of Neurology Clinic of First Affiliated Hospital of Xinxiang Medical College. Subject were divided into three groups, patients of migraine without aura (MO group), patients of migraine with aura (MA group) who has depression and anxiety disorder (comorbidity) and normal, healthy people (control group). The study used a survey approach. Sleep quality of subjects were analyzed by PSQI score and a whole night PSG. PSQI score and PSG monitor were in charge by trained health care professional (by a neurologist, an EEG physician, a technician and a nurse). The collected data were analyzed by using sigmastat3.5 statistical software for statistical description and analysis. Chi-square comparison was used for the count unit, case number (%) of units of measurement was compared by using mean ± standard deviation (x± s distribution, two groups using t test, three or more groups using one-way analysis of variance. Data that do not conform to the normal distribution used rank test.)Results1 The subjective sleep quality:Sleep of each of the three groups of subjects were scored by PSQI scale, it was statistically significant for MO and MA groups compared to the control group, (x2= 41.9225, the p value is 0.007<0.01, subjective sleep quality with non-premonitory migraine was lower than control group). There was no significant difference between MA groups and MO group.2 Polysomnography:There were statistically significances between patients and normal controls with exception of TIB, S1%, S2%. However, there was no significant difference between migraine groups (that is, MO group and MA group). In patients total sleep time decreased, sleep efficiency lowered and awaken occurred more often. On sleep architecture REM% increased compared with normal control group, SWS% decreased than that in the control group. Sleep latency and REM latency were longer.Conclusion1. There is no significant difference for subjective sleep or objective sleep between migraine with aura and migraine without aura.2. The quality of subjective sleep is poorer for patients with migraine than normal people, sleep pattern in patients with migraine is disturbed, sleep efficiency is lowered and sleep process is changed.3. The sleep in the migraine patients can be evaluated by PSQI score and PSG monitor system. |
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