| Objective:To investigate the clinical effect of repetitive transcranial magnetic stimulation (rTMS) therapy on Parkinson’s disease (PD) using Meta-analysis. Methods: Taking transcranial magnetic stimulation or TMS, Parkinson’s disease or PD and randomized controlled trial as retrival words, search related articles during 1999 to 2013 from PubMed, EMBASE, Ovid MEDLINE, VIP, Wanfang and China National Knowledge Intrastructure (CNKI). Finally 17 articles (4 in Chinese and 13 in English) were included for Meta analysis according to high frequency stimulation (HFS>1 Hz) and low frequency stimulation (LFS≤1 Hz) respectively. Results:A total pf 455 PD patients were enrolled and divided into TMS group (236 cases) and control group (219 cases). After HFS and LFS therapies, the Unified Parkinson’s Disease Rating Scale (UPRDS) score in TMS group was significantly different from control group (WMD=-5.010,95%CI:-7.370～-2.650, P=0.000; WMD=-6.140,95%CI:-8.750～-3.530,P= 0.000). After HFS therapy, the UPRDS III motor and activities of daily living (ADL) scores were statistical significances compared to control group(WMD=-3.960,95% CI:-7.400～-0.520, P= 0.020;WMD=-3.740,95%CI:-4.660～-2.820, P=0.000). There were no statistical significances in the UPRDS Ⅲ motor score with LFS therapy(WMD =-2.160,95%CI:-5.010～-0.690, P= 0.370) and the Mini-Mental State Examination (MMSE) score with HFS therapy between 2 groups(WMD=0.310,95%CI:-0.490～1.100,P=0.450). Conclusions:HFS and LFS therapies ameliorate partial symptoms of PD for enhancing the quality of life, however, improvement for cognitive impairment was not found. |
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