The Expression And Significance Of Soluble Endogin And Soluble Fms-like Tyrosine Kinase Receptor1to Predict Preeclampsia

Preeclampsia (PE) is one of the leading causes of maternal death, In2010, theincidence of worldwide is3~5%[1]; in the European and American countries, it is2~5%;in Asia and Africa, preeclampsia accounts for9%of the maternal mortality[2].10%~15%of maternal deaths or complications related directly to with complications of preeclampsiaand eclampsia[3].The definition of preeclampsia is the hypertension blood pressure(BP>140/90mmHg)、urine protein（>300mg/24h or+) and edema appearing at least twice with aninterval of4hours20weeks after the pregnancy and tending to be normal at6weekspostpartum[4].The etiology is still unknown, many scholars think that is the result of numerousfactors, such as maternal, fetal placenta. In2003Maynard etc found preeclampsia placentaexcessive expression of sFlt1, a large number of angiogenesis related serological indexes(sFlt-1, sEng, PlGF) has become the focus of the study. Some indicators can appear in earlypregnancy, and the detection method is simple, which has become the focus of research onprediction index of preeclampsia.Objective:The blood circulation in the elevated sFlt-1, sEng can predict the incidence ofpreeclampsia, to guide the clinical early diagnosis and timely application of sFlt-1andsEng inhibited the occurrence of prevention of preeclampsia clinical variables andtreatment provides good prospects.Materials and methods:This paper selected a total of45cases of pre eclampsia in pregnant women treatedin the Department of Obstetrics and Gynecology the second hospital of Jilin University from Sep.2014to Dec.2014period, including15cases of mild pre eclampsia. Maternal age(29.8±4.8) years old, pre pregnancy BMI (27.4±2.7) kg/m2, gestational age (36.0±2.7)weeks; group30cases of severe preeclampsia, maternal age (29.5±4.6) years old, prepregnancy BMI (30.4±4.4) kg/m2, gestational age (33.7±3.1) weeks. Randomly selectedover the same period in30cases of normal pregnancy as healthy control group, maternalage (29.6±4.9) years old, pre pregnancy BMI (26.7±3.6) kg/m2, collected gestational weeks(37.9±2.3) weeks. Using enzyme-linked immune adsorption test (ELISA) were detectedwith serum sEng and sFlt-1levels in pregnant women. Application of SPSS19.0statistics.Results:1.Comparison of serum sFlt-1, between the three groups.1) healthy control group, serum sFlt-1levels (353.98±97.96) pg/mL, mildpreeclampsia group (739.93±162.87) pg/mL, severe preeclampsia group (1285.21±234.70) pg/mL. After three groups of data were analyzed, the results showed a statisticallysignificant difference;2) mild preeclampsia serum sFlt-1levels(739.93±162.87) pg/mL, healthy controlgroup, serum sFlt-1(353.98±97.96) pg/mL, two were statistically significant differencebetween them;3) serum of severe preeclampsia(1285.21±234.70) pg/mL, healthy control group,serum sFlt-1levels (353.98±97.96) pg/mL, two were statistically significant differencebetween them;4) severe preeclampsia group serum sFlt-1levels (1285.21±234.70) pg/mL, mildpreeclampsia serum sFlt-1levels(739.93±162.87) pg/mL, two were statistically significantdifference between them.2.Comparison of serum sEng levels between the three groups.1) healthy control group, serum sEng level (329.97±78.05) ng/mL, mildpreeclampsia group (751.62±247.04) ng/L, severe preeclampsia group (1311.86±374.43)ng/L. On three groups of data were analyzed, the results showed a statistically significantdifference;2) mild preeclampsia serum sEng level (751.62±247.04) ng/mL, healthy control group, serum sEng level (329.97±78.05) ng/mL, two were statistically significantdifference between them;3) severe preeclampsia group serum sEng level (1311.86±374.43) ng/mL, healthycontrol group, serum sEng level (568.7±172.3) ng/L, two were statistically significantdifference between them;4) severe preeclampsia serum sEng level (1311.86±374.43) ng/mL, mildpreeclampsia serum sEng level (751.62±247.04) ng/mL, two were statistically significantdifference between them.Conclusion:Without complication conditions1pregnant women with preeclampsia serum sEng level was significantly increased,and related to the severity of the disease.2pregnant women with preeclampsia serum sFlt-1level was significantly increased,and related to the severity of the disease.