Clinical Study On Prevention And Treatment Of Age-related Macular Degeneration On The Basis Of Collateral Theory

Objective: Chinese medicine treatment of age-related macular degeneration has goodcurative effect, but its pathogenesis clinical research lack of unity in type. In this research,combined with the main pathogenesis of TCM clinical practice and use Collateral Theoryfrom "prolonged illness enters into venation" analysis of age-related macular degenerationmedicine treatment, the clinical syndrome and syndrome differentiation, which providenew ideas and methods for the treatment of the disease.Methods: Analysis of90patients with age-related macular degeneration (treatmentgroup), divided into early, middle and late3period,30cases each. According to CollateralTheory, including Meridian energy stasis type, Blood stasis winding resistance type,Phlegmy wet winding resistance type, Meridian deficiency type, the treatment groupwith complex treatment. One month a period of treatment, after3periods of treatment,Comparison before and after treatment in patients with ocular symptoms, eyesight,sharpness of vision, Fundus cumulative damage area (bleeding, seepage, etc.), glassmembrane warts, macular area, macular retinal thickness signs (in the case of leakage,bleeding, edema) and blood lipids, hemorrheology indexes, Other90patients (controlgroup) were retrospectively analyzed, including30cases in early, middle and late eachperiod, analysis of the outcome of patients with every period compared with the treatmentgroup.Results:(1) The eyesight of all patients were improved significantly after treatment(except10cases of blindness), there was no evident difference of2groups of patients withearly, middle and late treatment group than control group in improving.(2) All of thepatients vision clarity has improved significantly, there was no evident difference of2groups of patients with early, middle and late treatment group than control group inimproving.(3) All of the patients after treatment, fundus cumulative damage area (bleeding, leakage, etc.) had a distinct improvement.there was no significant difference between earlytreatment group and control group; Middle and late treatment group were better than thecontrol group effect.(4)In patients with middle and late glass membrane wartsimprovement after treatment, the treatment group is better than that of control group, therewas no evident difference early.(5) OCT detecting retinal thickness, Phlegmy wetwinding resistance type and Blood stasis resistance type complex retinal thickness inpatients with clinical changes before and after therapy is larger, treatment group better thancontrol group. but no change in both Meridian energy stasis type and Meridian deficiencytype in two groups.(6) Ophthalmoscope examination, all patients with blood stasis, edema,scar tissue is smaller; Treatment group early, mid and late damage area of improvementeffect is more apparent than in the controls.(7)In lipid metabolism and hemorrheology,compared with before treatment, significantly decreased the TC, TG, LDL-CH, VLDL-CH level, reduce the blood viscosity.(8) the synthetic evaluation of curative effect, totaleffective rate in treatment group, early, mid, and late were significantly higher than that ofcontrol group (P <0.05). Especially to control the disease progression, reduces the early tomiddle, medium-term development for the incidence of late (the treatment group wasbetter than the control group).Conclusion: With complex psychiatric disease pathogenesis theory analysis,individual differentiation, can effectively control the progress of age-related maculardegeneration, protect vision, improve patient quality of life. Age-related maculardegeneration has a good application prospect with Collateral theory.