The Level Changes Of The Urine Retinol Binding Protein In Patients With Primary Nephrotic Syndrome And It’s Clinical Significance

Objective:To investigate primary nephrotic syndrome patients with urinary retinolbinding protein level and it’s clinical significance,and renal tubular interstitial injurymechanism.Methods:Detection of30cases diagnosed parallel renal biopsy in patients with primarynephrotic syndrome and30cases of normal people as control group, the60cases wereexamined urine routine test and renal tubular function damage index, urine retinol bindingprotein (RBP), urine alpha1microglobulin (alpha1-MG), urine beta2-microglobulin(beta2-MG), N-acetyl-beta-D-glucosaminidase (NAG) content in urine, analyzingeach group RBP.In accordance with the biochemical examination results and the renaltubular interstitial damage score to do Spearman rank correlation analysis, and thedifferences and correlation between RBP and other indicators.Results:The extent of tubulointerstitium was positively correlated with urine RBP, alpha1-MG, beta2-MG, NAG(r=0.950，P＜0.01；r=0.837,P＜0.01；r=0.800，P＜0.01；r=0.957,P＜0.01). The specificity and sensitivity for the renal tubular injury of RBP were88.89%and90.48%. Conclusion:Urinary RBP can be sensitive to reflect the early primary nephrotic syndromepatients’pathological extent of the renal tubular injury,and compared with NAG,α1-MG,β2-MG is more sensitive.It’s positively correlated with the degree of renal tubulardamage.