Study On The Microporosity Osmotic Pump Tablets Of Rhododendron Total Flavonoids

Acanthopanax leaves flavonoids, is the general term of flavonoids extracted from the leaves of Acanthopanax is a class of Acanthopanax main active substances, can reduce myocardial oxygen consumption and blood stasis, Qi and spleen, sedative, and clear the veins Road and so on, used to treat angina, hypertension, coronary heart disease, cerebral infarction, cerebral thrombosis, cerebral arteriosclerosis, cerebral insufficiency and other cardiovascular diseases. Thus affecting their solubility and absorption in vivo, so that most ordinary preparations Acanthopanax leaves flavonoids low bioavailability. In this pa per, solid di spersion technology to improve the solubility and di ssolution Acanthopanax leaves flavonoids, and then made its porosity osmotic pump tabletsExperiments using sodiumn itrite-aluminum ni trate c hromogenic c olor, UV-visible sDectroohotometer t otal flavonoids. the a Dnlicabilitv of this m ethod. a ccurate. reliable, c onvenient. good to meet the entire experimental process quality control of the main active ingredient analytical requirements.To meet the demand for bulk drugs formulations to total flavonoid content as an indicator, the experiment using orthogonal design an optimum extraction process, and filter out macroporous resin s uitable for t he s eparation and purification oft otal flavonoids s ingle factor ex periments examine its separation and p urification of total flavonoids optimum conditions and parameters, experimental results show that the screening process is simple and feasible. Leaves flavonoids on Acanthopanax ex tracts w ere q uality c ontrol to m eet A canthopanax lea ves f lavonoids porous osmotic pump tablets production needs.Preparation of Acanthopanax leaves flavonoids solid dispersion, the effect of including the type and amount of support, preparation methods and other factors on the preparation of solid dispersions. Eventually filter out the best solution and prepare a more ideal solid dispersion. Preparation porosity osmotic pump tablets, using single factor method investigated tabletting method, the type and amount, the amount of filler penetration enhancers, and the amount of porogen PEG400, as well as the amount of plasticizer DBP impact of coating weight gain rate of drug release, and using f2similarity factor determining the s imilarity o f each release curve to d etermine the main factors affecting the drug release behavior of pro-consumption of sodium chloride penetration, porogen PEG400the a mount and rate of w eight gain coating. Then composite de sign-response s urface methodology to further opt imize the prescription and screening out t he most optimal results, a nd validated.Finally, total flavonoids were senticosus solid dispersions-porosity osmotic pump tablets Quality C ontrol. Ma inly on t he c haracter, i dentification, as say, a nd p reliminary s tability, preliminary results show that the stability of the formulation has some moisture should be closed dry place. However, high temperature, high humidity and accelerated testing of the preparations had no significant effect.