Observation On Zhike Pingchuan Recipe Granule Combined With Fuxiong Plaster Treat Post- Infectious Cough

Objective Post-infection cough, was often recurrent and refractory more frequently after their acute symptoms of upper respiratory tract infection disappears in children under five years old. The main features of clinical symptoms were the cough often recurrent for unknown case and persistent more than four weeks but less than eight weeks.Presently researches on pathological mechanism and fluticasone propionate treatment of Post-infection cough by western medicine were remain stagnant. Post-infection cough which have been called "cough" symptoms by our traditional medicine for thousands of years. Our traditional medicine treatment of Post-infectious cough has obvious advantages, researches on traditional Chinese medicine in treatment of post infectious cough gradually increase in recent years. Using traditional Chinese medicine prescription named Zhike Pingchuan recipe granule for drinking combined with Fuxiong plaster for extemal application as a treatment program, then to observe the effect in treatment of Post-infectious cough which divided into a type of phlegm-damp amassing in lung base on Chinese medicine syndrome differentiation.Methods with the strict requirements of medical research, one hundred and ninty two cases who go to department of Traditional Chinese Medicine, Wuhan Children Hospital from June 2013 to June 2014.They were all conform to the western medicine diagnostic criteria of Post-infectious cough in children and the criteria of Chinese medicine. They were divided into therapy group,western medince group and plaster group at random. There were seventy-three hundred children using Montelukast Sodium Chewable Tables 4mg for once a day and the other drops for tailoring treatments were assigned to western medince group. While fifty-seven children only using Fuxiong plaster for extemal application were assigned to the plaster group,put it on two speciously acupoint on the skin of the back for a few minutes a day which depended on their age and the time their skin tend to red. And hundred children drinking Zhike Pingchuan recipe granule which was dissolved in 30 ml to 50 ml water every time,and drinking it for three or four times a day,and combine with Fuxiong plaster as the therapy group.Cough was divided into six level by Cough Scores, which finished by doctors or the children’s guardian. Analysis the records of all collected about the state of an illness, symptoms, signs and other data with SPSS15.0,and separately compared the date before and after two weeks treatment. To determine the efficacy and comparison of curative effect was carried out according to the statistical method.Results The mean age of Post-infection cough onset and the female-to-male ratio in therapy were both had no significant differences with the three control groups(P>0.05). Time of disease varied and the patient acuity in therapy had no significant differences with the three control groups(P>0.05). The result of laborator text contain blood routine, liver function test and renal function both had no significant differences with the three groups(P>0.05). After treatment, the frequency and severity of the cough symptoms were effectively controlled and their living quantity improved obviously. There were 33 cases curative in therapy group, and 22 cases obviously, then 6 cases improved, only 1 cases ineffective in the therapy group, the total efficiency of the group was 88.7%; There were 23 cases curative, 31 cases obviously,14 cases improved,5 cases ineffective, the total efficiency of western medince group was 73.97%; There were 14 cases curative, 23 cases obviously,13 cases improved,7 cases ineffective, the total efficiency of plaster group was 64.91%. The comparison of clinical curative effect between the three groups was statistically significant(P < 0.05). Time of producing cough relieving effect: the therapy group need 3.12±1.95 days, while the western medince group need 4.57±1.78 days, and the plaster group need 3.76±1.86 days,which was significantly shorter than that in the control(P<0.01); The day scores of cough symptoms in thrapy group was lower than the other two groups(P < 0.01).Repeated infection rate in thrapy group was lower than the control groups, and was statistically significant(P<0.01).Conclusion Observation on traditional Chinese medicine Zhike Pingchuan recipe granule for drinking combined with Fuxiong plaster for extemal application in treating Post-infection cough in children shows that the frequency, time, severity, duration of the disease in the therapy group which had significant improvement was lower than those in the control groups. The curative effect of therapy group was better than Montelukast Sodium Chewable Tables combined with the cough drops or using Fuxiong plaster exclusivly. There were no adverse reactions in the three groups of patients during our clinical observation. Zhike Pingchuan recipe granule was conducive to relieve the symptom of Post-infection cough,and improved the living quality of these children who got Post-infection cough and kept them away from cough day and night.