The Investigation Of The Relationship Between Systemic Lupus Erythematosus TCM Syndrome Type And Pathological Changes Of Laboratory Indexes And System

Objectives:Through the retros Pective analysis method,this study was to explore the TCM syndrome tyPes in Patients with systemic luPus erythematosus (SLE) distribution, and the relationship between laboratory index and the Pathological changes of viscera system.This study was for the diagnosis and assessment of systemic luPus erythematosus (SLE) to Provide effective basis.Methods:This study collected all the information (gender, age, TCM syndrome tyPes, laboratory index and Pathological viscera system, etc.) of standard Patients who was hosPitalized at Chinese medicine hosPital of Jiangsu Province rheumatology between 2009-01-01 and 2014-12-31.The Patients devided into several grouPs according to TCM syndrome tyPe of the 2002 Chinese medicine new medicine clinical research guiding principle.ResPectively, through statistical data of each syndrome tyPe of traditional Chinese medicine clinical indicators, we can include the distribution of each tyPe of syndrome and the correlation of each tyPe of syndrome and clinical indicators.Results:This study included 263 cases of SLE Patients that match the standard.①Routine blood test:the value of each tyPe of white blood cell difference statistically significant (P<0.05), among the various tyPes of hemoglobin and Platelet values showed no statistically significant difference (P>0.05). ② ESR values of each tyPe, and 24-hour urine Protein quantitative difference statistically significant (P<0.05). ③ syndrome globulin difference statistically significant (P<0.05).④ Patterns there is significant difference between the IgG value (P<0.05), but no statistically significant differences between IgA and IgM values (P>0.05). ⑤ Patterns complement C3, there were statistically significant differences between C4 (P<0.05). f Patterns between anticardioliPin antibody-Positive rate difference was not statistically significant (P>0.05), the difference between direct Coomb’s syndrome Positive rate was statistically significant (P<0.05.) sadly no differences among the various syndromes of ANA Positive rate was statistically significant (P>0.05). The ANA karyotyPic difference was statistically significant(P<0.05). ⑧Each tyPe anti-Sm antibody Positive rate were significantly different (P<0.01),The syndromes of resistance to ds-DNA,SSA, SSB Positive rates were statistically significant differences between (P<0.05).⑨Patterns of Pulmonary artery Pressure (estimated) the difference was statistically significant (P<0.05).⑩Patterns SLEDAI there was a significant difference between assessment scores (P<0.05). 11 sPleen kidney Yang deficiency syndrom aPPeared kidney system damaged ProPortions SuPreme, qi and xue deficiency syndrom minimum, both between differences has statistics meaning (P<0.05); yu and re obstruction syndrom aPPeared blood system damaged Proportions SuPreme, qi and xue deficiency syndrom minimum, both between differences has statistics meaning (P<0.05); re and du ascending syndrome aPPeared neural sPirit system lesions Proportions SuPreme, qi and xue deficiency syndrom minimum, both between differences has statistics meaning (P<0.01); yu and re obstruction syndrom aPPeared heart variable Proportions SuPreme, qi and xue deficiency syndrom minimum, There is significant difference between the two (P<0.05)Conclusion:Laboratory indexes and Pathologic correlation varies between different TCM syndromes. Laboratory Parameters in the link include:leukocyte, erythrocyte sedimentation rate, and 24-hour urine Protein, globulin, complement C3, C4, Coomb’s, ANA karyotyPe test Positive rates directly, autoantibody-Positive rate (ds-DNA and the Sm and the SSA, and SSB), Pulmonary artery Pressure and SLEDAI score, these indicators of clinical syndrome differentiation and tyPing of traditional Chinese medicine, certain significance in guiding treatment. Immunoglobulin IgA, IgM and anti-cardioliPin antibody, total ANA Positive rate and no significant correlation between syndrome differentiation of traditional Chinese medicine, its unity only as for the SLE laboratory indicators to guide clinical differentiation is not sPecific. Involved organs system and there is a close correlation between syndrome tyPes of traditional Chinese medicine, esPecially heat toxin hyPeractivity with the nervous system, sPleen-Yang deficiency and kidney systems, mixed stasis-heat stasis syndrome and blood systems, stagnated heat of bi syndrome with cardiac system, syndrome of endogenous heat due to Yin deficiency and lung system and this has imPortant significance for clinical syndrome differentiation and treatment.