A Study Of Serum Levels Of NMDAR Antibody、NRG1、 NSE In The First-episode Schizophrenia

Objective:To explore serum levels of NMDAR antibody、NRG1、NSE three protein factors in the first-episode schizophrenia before and after therapy, research the correlations between three protein factors and the pathogenesis、clinical symptoms、cognitive function of schizophrenia,also study the correlations of three protein factorsMethods:Our study used case-control.The serum concentrations of three protein factors in 82 patients with the first episode schizophrenia (before and after treated) and 80 healthy controls were assayed by ELISA respectively. All patients were treated with risperidone for 6 weeks. The severity of schizophrenia and response to treatment were assessed with the positive and negative syndrome scale (PANSS). The cognitive function of schizophrenia and healthy controls were assessed with MCCB.Results:① The concentrations of serum NMDAR antibody、NSE are observably higher than healthy controls[(208.84±113.60)vs(107.29±40.57)pg/ml, (26.74±12.78) VS (11.24±3.36) ug/L],but NRG1 are markedly lower than healthy controls[(11.39±5.06)VS(16.95±8.06)pg/ml] in the first-episode schizophrenia.②The concentrations of serum NMDAR antibody、NSE are dramaticlly lower after treated with risperidone[(159.25±69.42)VS(208.84±113.60)pg/ml,(17.01±8.08) VS(26.74±12.78)ug/L] while NRG1 increasing[(17.32±7.33)VS(11.39±5.06)pg/ml],P <0.01.③There are positive correlations for the concentrations of serum NMDAR antib ody and NSE with the PANSS total score,but there are no correlations after treated for NMDAR antibody while NSE still remain the correlations.The concentration differen ce of NMDAR antibody and NSE concentrations before and after therapy are positiv e correlated with the differences of PANSS scores but there no correlations for NR G1.④The concentrations of serum NMDAR antibody have positive correlation with NSE concentrations, but there are no correlations between NRG1 and NMDAR antibody or NSE in the first episode schizophrenia before and after therapy.There are no correlations among the concentration difference of NMDAR antibody、NRG1 and NSE.⑤The T scores of seven field of MCCB cognitive function examination for research group are lower than healthy control by t Test.⑥The concentrations of serum NMDAR antibody and NSE but no NRG1 are negatively correlated with WMS-III SS scores in MCCB cognitive function test while other six fields all no correlation in first-episode schizophrenia by Pearson correlation analysis.Conclusion: ①The concentrations of serum NMDAR antibody and NSE are observably higher than healthy controls while NRGl are markedly lower than healthy controls in the first-episode schizophrenia.It prompts that there are psychoneuroim-munology inflammatory reaction, nerve injuries, neuronal apoptosis and lack neuro protect, so it is necessary to treat in prodromal stage or high risk period for schizophrenia.②The concentrations of serum NMDAR antibody, NSE are dramaticlly lower after treated with risperidone while NRG1 increasing, it predicts that antipsychotics can reverse psychoneuroimmunology inflammatory reaction, nerve injuries and promote neuron protect and repair.③The concentrations of serum NMDAR antibody and NSE can preferably reflect schizophrenia clinical symptom and curative effect.④There are positive correlations between NMDAR antibody and NSE in first-episode schizophrenia also their concentration differences before and after therapy.The proteins of NMDAR antibody and NSE play a important role in schizophrenia athogenesis also they are close relationship.⑤ Schizophrenia patients exist wide cognitive function lesion than healthy people.