Studies On Chemical Constituents Of Podocarpus Fleuryi Hickel

The thesis mainly reported studies on chemical constituents of Podocarpus fleuryi Hickel. Totally 38 constituents were isolated and elucidated from the leaves and twigs of Podocarpus fleuryi Hickel, two is a new compounds.By solvent extraction, silica gel column chromatography, MCI column chromatography and Sephadex LH-20 column chromatography, 28 compounds were isolated from the leaves of Podocarpus fleuryi Hickel, and all of them were identified by by various spectral methods(1H-NMR, 13C-NMR, HMQC, HMBC, 1H-1H COSY, NOESY, and MS) to be as stigmasta-B-nor-6β-formyl-3β, 5β-diol(1), stigmast-5-ene-7α, 22α-diol-3β-tetradecanoate(2), 1β, 6α-dihydroxy-4(14)-eudesmene(3), 9α-hydroxy-1β-methoxycaryolanol(4), aromadendrane-4β,10β-diol(5), caryolane-1,9β-diol(6), 4-megastigmen-3,9-dione(7),(3R, 6R, 7E)-3-hydroxy-4,7-megas-tigmadien-9-one(8),(4S*,6R*)-4-hydroxy-4,8,8-trimethyl-9-oxabicyclo[4.2.1]-non-1-en-3-one(9), dehydrovomifoliol(10), vomifoliol(11), roseoside(12), α-onocerin(13), 4-hydroxy-3-methoxyb-enzaldehyde(14), 3,4,5-trimethoxycinnamyl alcohol(15), p-hydroxybenzoic acid(16), 3-hydroxy-4-methoxy enzoic acid(17), 1-(4-hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one(18),(R)-3-Hydroxy-1-[(R)-4-hydroxy-1,3-dihydroisobenzofuran-1-yl]butan-2-one(19), 8,8′-dihydroxypinore-sinol(20), α-tocopherol-quinone(21), chrysoeriol(22), podocarpusflavone B(23), sciadopitysin(24), kayaflavone(25), amentoflavone-7,7’’,4’,4’’’-tetramethyl ether(26), podocarpusflavone A(27), 7,7’’,4’-trio-methyl amentoflavone(28). Compound 1 was a new compound and others were isolated from the plant for the first time except compounds 16, 22-28.From the twigs of Podocarpus fleuryi Hickel, 11 compounds were isolated by by various spectral and were identified as stigmasta-B-nor-formyl-3β, 5β, 6-diol(29), stigmast-4-en-3-one(30), β-sitosterol linoleate(31), rearranged pimarane-type diterpene alcohol(32), inumakoic acid(33), lambertic acid(34), secoisolariciresinol-9,9’-acetonide(35), 3, 4-dimethoxybenzyl alcohol(36), p-hydroxybenzyl alcohol(37), chrysophanol(38),(-)-epicatechin(39). Compound 29 was a new compound and others were isolated from the plant for the first time except compounds 34.At last, pharmacological studies of megastigmane families were reviewed, including 386 megastigmane compounds and their names, structures, plant resources, pharmacological activities and references were cited.