The Analysis Risk Factors Of Nonalcoholic Fatty Liver Disease

Objective:1. Clear the risk factors and the independent risk factors of nonalcoholic fatty liver disease in the crowd of health physical examination of the First Hospital of shanxi Medical University;2. Analysis of nonalcoholic fatty liver disease in simple fatty liver, adipose sex hepatitis and liver cirrhosis independent risk factors for the development of three stages;3. Provide a scientific basis for the sake of nonalcoholic fatty liver disease prevention and control. Methods:Collecting the results of physical examination from physical examination center of the first hospital of shanxi medical university, from April 2014 to October 2014. Taking physical examination results of 200 patients with NAFLD as observation group, 200 non-fatty liver as control group.Investigated and recorded the objects of study of gender, age, height, weight, BMI, systolic pressure, diastolic blood pressure, WBC, RBC, HGB, PLT, ALT, γ-GT, HDL, LDL, BUN, SCR, total cholesterol, triglycerides, fasting glucose, abdominal ultrasound and other indicators, ask for details of their eating habits, whether took regularly physical exercise, past medical history, family history, drinking history, analysed the relationship among NAFLD with BMI, systolic pressure, diastolic blood pressure, total cholesterol, triglycerides, the relationship and the fasting plasma glucose. After it, took the multi-factor Logistic regression analysis.According to the level of ALT and imaging examination, the observe group is divided into three groups: simple fatty liver(NAFL), adipose sex hepatitis(NASH), NASH related cirrhosis. After it, using analysis of variance analysis of nonalcoholic fatty liver disease at various stages of the independent risk factors. Results:In the crowd of 1298 cases of physical examination, check out the 200 cases of fatty liver patients(15.41%). In observation group of 112 men and 88 women(except pregnant women), the sex ratio of 1.27:1, average age 44.03±9.51 years old. The control group Male 109, female 91(except pregnant women); atio is 1.20:1, an average age of 44.86±10.87 years old.The single factor analysis results : High-fat and high-calorie diet, irregular movement, BMI, systolic pressure, diastolic pressure, white blood cell count, red blood cell count, hemoglobin count, ALT, γ-GT, triglyceride, cholesterol, low density lipoprotein cholesterol, fasting blood glucose, blood uric acid levels, blood urea nitrogen, serum-creatinine, these variables observation group is higher than the control group, the difference was statistically significant(P<0.05).Observation group of high-density lipoprotein cholesterol is lower than the control group, the difference statistically significant(P<0.05).Age, gender, and the platelet count there was no statistically significant difference between the observation group and control group(P>0.05). Logistic regression analysis results showed that: there are four factors finally entered the regression equation, the independent risk factors for NAFLD occurs, namely high BMI(OR=1.357), fasting blood glucose(OR=1.645), elevated triglycerides(OR=1.095), elevated blood uric acid(OR=1.023).NAFL group, 95 cases in observation group(47.5%), NASH group 87 cases(43.5%), and NASH related cirrhosis group of 18 cases(9%).Variance analysis results showed that: BMI in NAFL group(25.83±2.45), NASH(26.88±2.52), and NASH related cirrhosis group(25.84±1.79) between the F value was 4.57, there was no statistically significant difference(P>0.05), multiple comparison results: NAFL group with NASH group difference was statistically significant(P<0.05), NAFL group cirrhosis associated with NASH, NASH and NASH related cirrhosis group has no statistically significant difference(P>0.05);Fasting blood glucose levels in NAFL group(5.42±0.83), NASH(5.74±1.25), and NASH related cirrhosis group(6.76±1.62) between the F value is 11.234, multiple comparison results NAFL group with NASH, NAFL group cirrhosis associated with NASH fasting glucose levels meaningful difference(P<0.05), while differences NAFL group with NASH meaningless(P>0.05);Triglycerides in NAFL group(1.84±0.85), NASH group(2.31±1.01), and NASH related cirrhosis group(2.19±0.91) between the F value is 5.978, multiple comparison results: NAFL group with NASH group difference was statistically significant(P>0.05), NAFL group and cirrhosis of the liver, NASH and NASH related cirrhosis group differences between meaningless(P>0.05);ALT levels in NAFL group(24.12±8.44), NASH(56.13±15.71), and NASH related cirrhosis group(145.56±40.81) between the F value is 404.725, multiple comparison results: three groups of ALT levels meaningful difference(P<0.05); γ-GT levels in NAFL group(29.14±10.79 mm), NASH(53.00±47.97), and NASH related cirrhosis group(86.83±43.04) between the F value is 24.979, multiple comparison results: three groups of γ-GT level difference significant(P < 0.05);Blood uric acid levels in NAFL group(374.66±63.436), NASH(398.79±70.70), and NASH related cirrhosis group(506.17±52.31) between the F value is 30.217, multiple comparison results: three groups of uric acid level difference significant(P<0.05). Conclusions:Ranked among the 1298 cases of medical detection in patients with NAFLD, 200 check-up crowd NAFLD prevalence was 15.41%, that of shanxi medical university first hospital check-up crowd prevalence of NAFLD and NAFLD, about the same in China, may be linked to a medical diet structure, with the crowd, economic development and average level in our country.High-fat high-calorie diet, irregular movement, BMI, systolic pressure, diastolic pressure, white blood cell count, red blood cell count, hemoglobin count, ALT, γ-GT, triglyceride, cholesterol, low density lipoprotein cholesterol level, fasting blood glucose, blood uric acid levels, blood urea nitrogen, serum creatinine, rise the indicators are the risk factors of NAFLD.In which high BMI, elevated ALT elevations, γ-GT, fasting blood glucose, elevated triglycerides, blood uric acid increased as the independent risk factors for the development of NAFLD.In all stages of NAFLD should pay attention to control weight.In NASH and related cirrhosis stage should pay attention to control blood sugar.There is little difference at all stages NAFLD lipid control.At various stages in NAFLD pay attention to control the ALT, γ-GT, blood uric acid, as it should take to late.