Assessment Of Clinical Biochemistry Detection System Of Diagnostic Index Of Metabolic Syndrome In 5 Laboratories In Gansu And Epidemiological Features Of Metabolic Syndrome In 5 Cities

Objective To investigate the prevalence of metabolic syndrome in Gansu provinnce.Methods A multistage stratified cluster sampling method was conducted. A total of 6609 adults(range 18-96 years old) from 5 cities located in different areas of Gansu province were included in the analyses and all of them underwent physical examinations. Assessment of clinical biochemistry detection system of diagnostic index of Metabolic Syndrome in 5 Laboratories, Metabolic syndrome was diagnosed under the modified 2005 National Cholesterol Education Program Adult Treatment Panel Ⅲ(ATPⅢ) guidelines as well as the 2004 Chinese Diabetes Society(CDS) guidelines.Results1. The number of related laboratory personnel in Gansu Provincial Hospital, Qingyang People’s Hospital, Jiuquan Steel Hospital, Linxia People’s Hospital and Longnan People’s Hospital who bachelor degree or above are 7, 4, 2, 5 and 4, who chief laboratorian or above are 5, 4, 3, 2 and 4. All related personnel have been trained in Gansu Provincial Hospital. The worst FPG precision is 2.82%(Jiuquan Steel Hospital). The worst TG precision is 3.24%(Jiuquan Steel Hospital). The worst TC precision is 2.91%(Linxia People’s Hospital). The worst HDL-c precision is 2.82%(Linxia People’s Hospital). The worst LDL-c precision is 4.52%(Longnan People’s Hospital). The worst UA precision is 3.41%(Longnan People’s Hospital). The FPG Proficiency Test of Jiuquan Steel Hospital is 80% in the first test of 2013. The TG Proficiency Test of Longnan People’s Hospital is 80% in the first test of 2014. The other items Proficiency Test of the 5 hospitals are 100%. The test methods of FPG, TG, TC, HDL-c, LDL-c and UA are glucose oxidase and peroxidase, GPO-POD, Cholesterol Oxidase and Peroxidase, Polyanion-Polymer Detergent, Protection Detergent and Urate Oxidase. The Reference Interval of FPG, TG, TC, HDL-c, LDL-c and UA are 3.9-6.1 mmol/L, 0.34-1.80 mmol/L, 2.85-5.85 mmol/L, 1.04-1.95 mmol/L and 2.0-3.1 mmol/L, 214-440 μmol/L(male); 150-350 μmol/L(female).2. All 5 cities population: Using the modified ATPⅢ criterion for diagnosis, the unadjusted prevalence of metabolic syndrome was 30.43%(35.25% in males and 23.02% in females, respectively), and the age-adjusted prevalence was 29.05%. The prevalence of MS from 18-34, 35-44, 45-54, 55-64, 65-74 and 74-96 years age group are 15.23%, 26.90%, 35.96%, 42.10%, 46.37% and 41.61%. The prevalence of metabolic syndrome was increased with age. Combination with central obesity, High TG hyperlipidemia and low HDL-c hyperlipidemia was the most frequently seen. Significant difference was found in the prevalence of MS between different ethnicities. The relative coefficient between the prevalence of MS and serum non-HDL-c or serum uric acid, respectively, is 0.25 and 0.11. The prevalence of hyperuricemia in MS group was 26.24% which was higher than that in the others(14.03% in partical abnormal group and 6.60% in normal group). Under the CDS criterion, the unadjusted prevalence of metabolic syndrome was 13.42%(17.34% in males and 7.41% in females, respectively), and the age-adjusted prevalence was 12.65%. The prevalence of metabolic syndrome was increased with age.3. A low level of agreement in the prevalence in MS between the ATPⅢ and CDS was observed(Kappa index=0.496).Conclusion1. The ablity of related laboratory personnel can afford the research requirement. The diagnostic index results of metabolic syndrome are in agreement with those determined by 5 laboratories.2. There was a big difference in the prevalence in MS among the population of 5 cities’.The prevalence of metabolic syndrome in Longnan is the highest. The prevalence of low HDL-c hyperlipidemia in Jiayuguan is high.3. The prevalence of metabolic syndrome in the 5 cities in Gansu is higher than that domestically formerly reported.4. Compared with CDS diagnostic criteria, under the ATPⅢ, more patient with early stage of MS were identified thus could be recommended as the preferred diagnostic criterion.5. The serum non-HDL-c has a stronger correlation with metabolic syndrome than serum LDL-c; The serum UA in MS group is higher than that in non-MS group.